凌 勇

编辑:药学院 | 阅读: 次 | 发布时间:2012-11-04


凌勇:男,1982年2月生,副教授, 硕士研究生导师,国家青年科学基金和江苏省自然基金获得者,江苏省“六大人才高峰”高层次人才B类培养对象。2003年6月南京工业大学化学工程与工艺专业本科毕业,获工学士学位;2007年6月南京工业大学应用化学专业硕士研究生毕业,获理学硕士学位;2010年6 月中国药科大学药物化学专业博士研究生毕业,获理学博士学位。现为中国药学会会员。从事创新药物研究与开发,主要研究Ras蛋白、HDAC及NF-κB等抑制剂,以及纳米载药功能、多重靶向前药等抗肿瘤药物、抗炎药物设计。近五年主持国家和省部级、国家重点实验室课题及市厅级课题5项。在药物化学权威期刊JMC、OBC、BMC等发表SCI文章20余篇。获得授权发明专利7项。
近五年第一作者或通讯作者代表作:
1. Novel Nitric Oxide-releasing Derivatives of Farnesylthiosalicylic Acid: Synthesis and Evaluation of Anti-hepatocellular Carcinoma Activity. J. Med. Chem . 2011, 54 (9), 3251-3259.
2. Synthesis and biological evaluation of hybrids from farnesylthiosalicylic acid and hydroxylcinnamic acid with dual inhibitory activities of Ras-related signaling and phosphorylated NF-κB. Org Biomol Chem . 2014, 12(25):4517-30.
3. Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents, Bioorg. & Med. Chem . 2014, 22 (1), 374–380.
4. Hybrids from Farnesylthiosalicylic Acid and Hydroxamic Acid as Dual Ras-Related Signaling and Histone Deacetylase (HDAC) Inhibitors: Design, Synthesis and Biological Evaluation. ChemMedChem. 2015, 10, 971 –976.
5. Novel FTS-diamine/cinnamic acid hybrids inhibit tumor cell proliferation and migration and promote apoptosis via blocking Ras-related signaling in vitro. Cancer Chemother Pharmacol. 2015, 75(2):381-92.
6. Hybrid molecule from FTS-diamine and phenylpropenoic acid as Ras-related signaling inhibitor with potent antitumor activities. Chem Biol Drug Des. 2015, 85(2):145-52 .
7. Synthesis and biological evaluation of nitric oxide-releasing hybrids from gemcitabine and phenylsulfonyl furoxans as anti-tumor agents. Med. Chem. Commun ., 2015, 6, 1130–1136.
8. Synthesis and biological evaluation of novel farnesylthiosalicylic acid derivatives for cancer treatment. Arch. Pharm. Chem. Life Sci., 2014, 347, 327–333.
9. Benzylidene 2-aminoimidazolones derivatives: synthesis and in vitro evaluation of anti-tumor carcinoma activity, Chem. Pharm. Bull.2013, 61(10), 1081-1084.
10. Novel pleuromutilin derivatives as antibacterial agents: Synthesis, biological evaluation and molecular docking studies. Bioorg. & Med. Chem. Lett. , 2012, 22(19), 6166-6172.
11. Design, Synthesis and Antibacterial Activity of Novel Pleuromutilin Derivatives Having Amino Thiazolyl Ring, Arch. Pharm. Chem. Life Sci., 2012, 345(8), 638–646.
12. Synthesis and neuroprotective effects of the fluorine substituted salidroside analogues in the PC12 cell model exposed to hypoglycemia and serum limitation. Chem. Pharm. Bull . 2013, 61(11) 1192–1196.
13. Identification of gut microbial metabolites of a synthetic nitric oxide-releasing farnesylthiosalicylic acid derivative, an antitumor agent. Analytical Letters.2014, 47, 191-201.
14. Synthesis and biological evaluation of novel farnesylthiosalicylic acid/salicylic acid hybrids as potential anti-tumor agents, Chin. Chem. Lett. , 2014, DOI: 10.1016/j.cclet.2014.06.021.
15. Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents, Chin. Chem. Lett. , 2013, 24(8), 727-730.
16. Synthesis and in vitro biological evaluation of farnesylthiosalicylic acid derivatives as anti-tumor carcinoma agents, Chin. Chem. Lett., 2012, 23 (10), 1141-1144.