朱红艳

师资介绍

朱红艳，女，汉族，1978年6月生，博士，教授，硕士生导师。

教育经历：

1995.09-2000.06南通医学院，临床医学，学士

2003.09-2006.06南通大学医学院，航空、航天与航海医学专业，硕士

2008.09-2011.12中国药科大学，微生物与生化药学专业，博士

2015.09-2016.09美国密歇根大学安娜堡分校，药学专业，访问学者

工作经历：

2000.07-2012.08南通大学，医学院，讲师

2012.08-2018.11南通大学，药学院，副教授

2018.11-至今  南通大学，药学院，教授

研究方向：

仿生药物递送系统，核酸药物递送系统，肿瘤综合治疗

社会学术兼职：无

基金项目：

1. 江苏省自然科学基金面上项目，BK20201443，靶向调控肿瘤转移前微环境的工程化“外泌体影”仿生递释系统研究，2020/7-2023/6，10万元，在研，主持 ；

2. 国家自然科学基金青年基金项目，81202467，胞内触发释药的仿生型siRNA自组装胶束纳米复合物的构建、抗肿瘤转移作用及细胞内药物动力学研究，2013/1-2015/12，23万元，已结题，主持 ；

3. 江苏省青年科学基金项目，BK2012232，靶向肿瘤血管生成的仿生型小核酸药物递释系统研究，2012/7-2015/7，20万元，已结题，主持 ；

4. 江苏省教育厅高校自然科学研究面上项目，11KJB350004，谷胱甘肽触发释放的智能型siRNA复合载体（穿膜肽Tat-壳聚糖-量子点）的构建及其抗肿瘤活性研究，2011/01-2014/12，3万元，已结题，主持 ；

5. 江苏省高校自然科学研究指导性项目，06KJD310150，南瓜多糖对链脲菌素诱导的胰岛损伤的保护作用及机制研究，2007/01-2008/12，1万元，已结题，主持；

6. 南通市课题，Exosome@CBSA仿生siRNA递送系统的构建及其抗乳腺癌术后转移作用研究，2018.07-2020.06，项目编号：JC2018024，5万元。

科研成果：

朱红艳老师始终保持博采勤思的学习习惯和开拓创新的工作态度，勤钻业务，勇于创新，大胆创造性地工作。在本职工作领域取得了一些成绩，获得了省微课比赛三等奖，以及校本科毕业实习优秀指导老师，指导本科生论文获江苏省优秀毕业论文二等奖。多次指导学生参与省级、校级大学生创新创业项目，并指导学生在SCI、国家核心期刊上发表相关研究论文。朱红艳近五年主要从事新型药物递释系统研究，研究方向主要有仿生药物递送系统、核酸药物递送系统、肿瘤综合治疗等。目前已经以第一作者或通讯作者的身份发表SCI论文20篇、中文核心期刊数篇，获授权发明专利3项，主持完成国家、省级、教育厅等多项课题。

成果奖励：

1. 南通大学优秀党员

代表性论文：

1. Lixing Xu, Xiao Du, Yao Zhou, Xinyu Cao, Ying Shen, Hongyan Zhu,* and Haiqin Huang*. Polyaspartic Acid-Stabilized CaCO3Containing In Situ Hydrogel for Protection and Treatment of Gastric Ulcer. Mol. Pharmaceutics. 2023, 20(4):2105-2118.

2. Haiqin Huang, Lanlan Shao, Yan Chen, Weili Han, Yao Zhou, Tianqing Liu, Jinhua Gu,* and Hongyan Zhu*. Sequential Dual Delivery System Based on siCOX-2-Loaded Gold Nanostar and Thermal-Sensitive Liposomes Overcome Hypoxia Mediated Multidrug Resistance in Tumors. Mol. Pharmaceutics. 2022, 19(7):2390-2405.

3. Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Hongyun Li, Hongyan Zhu* and Tianqing Liu*. Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer. Journal of Nanobiotechnology. 2022, 20:359.

4. Haiqin Huang, Lanlan Shao, Yan Chen, Lan Tang, Tianqing Liu, Junxu Li, and Hongyan Zhu*. Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer. Bioeng Transl Med. 2021, 7(2):e10284.

5. Shengyu Zhang, Ye Gan, Lanlan Shao, Tianqing Liu, Danyi Wei, Yanyan Yu,* Hongwei Guo,* and Hongyan Zhu*. Virus Mimetic Shell-Sheddable Chitosan Micelles for siVEGF Delivery and FRET-Traceable Acid-Triggered Release. ACS Appl. Mater. Interfaces. 2020, 12, 53598-53614.

6. Liuwan Zhao,Chunyan Gu,Ye Gan,Lanlan Shao,Hongwei Chen,Hongyan Zhu*. Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis. J Control Release. 2020, 318, 1-15.

7. Hongyan Zhu,Weili Han,Ye Gan,Qiaofeng Li,Xiaolan Li,Lanlan Shao,Dan Zhu* andHongwei Guo*. Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma. Pharmaceutics 2019, 11(12), 683

8. Yanyan Yu, Min Zhou, Wei Zhang, Lei Huang, Dandan Miao, Hongyan Zhu*, Gaoxing Su*. Rattle-Type Gold Nanorods/Porous-SiO2 Nanocomposites as Near-Infrared Light-Activated Drug Delivery Systems for Cancer Combined Chemo-Photothermal Therapy. Mol. Pharmaceutics. 2019,16(5) 1929-1938

9. Su G, Miao D, Yu Y, Zhou M, Jiao P, Cao X, Yan B, Zhu H*. Mesoporous silica-coated gold nanostars with drug payload for combined chemo-photothermal cancer therapy.J Drug Target. 2019 Feb; 27(2):201-210. 

10. ShengyuZhang, YanjunLiu, YeGan, NanqingQiu, YueqingGu, Hongyan Zhu*. Conjugates of TAT and folate with DOX-loaded chitosan micelles offer effective intracellular delivery ability.Pharm Dev Technol. 2019, 24(2):253-261.

11. Shengyu Zhang, Liuwan Zhao, Nanqin Qiu, Yanjun Liu, Bohui Xu, Hongyan Zhu*, On the hypoxic tumor targeting ability of two chitosan micelles loaded with oil-soluble CdSe quantum dots.Pharm Dev Technol. 2018, 23(1):87-95.

12. Hongyan Zhu*, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu and Gaoxing Su*, Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment.Int J Mol Sci. 2017, 18(10):2029.

13. Fei Liu, Yuan Sun, Chen Kang, Hongyan Zhu*. Pegylated drug delivery systems: from design to biomedical applications. Nano Life. 2016, 6(3, 4):1642002 (1-11).

14. Bohui Xu, Yubin Wang, Hongyan Zhu*. Mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: Preparation and pharmacokinetics in beagle dogs. Pharmazie. 2016 71(2):76-83.

15. Hongyan Zhu, Shengyu Zhang, Yongling, Guoliang Meng, Yu Yang, Wei Zhang*. pH-responsive hybrid quantum dots for targeting hypoxic tumor siRNA delivery. J Control Release. 2015, 220(Pt A):529-544.

16. Hongyan Zhu, Guangtong Chen, Guoliang Meng Jiliang Xu*. Characterization of pumpkin polysaccharides and protective effects on streptozotocin-damaged islet cells. Chin J Nat Med. 2015, 13(3):199-207.

17. Hongyan Zhu, JingPing Zhu, AiMei Xie, Yong Lin, BeiBei Zhang, YiFei Wang, Wei Zhang*.Visible quantum-dot-based targeted siRNA delivery for HIF-1α gene silencing. J. Drug Del. Sci. Tech. 2014, 24 (5): 445-451.

18. Hongyan Zhu, Jie Cao, Sisi Cui, Zhiyu Qian, Yueqing Gu*. Enhanced tumor targeting and antitumor efficacy via hydroxycamptothecin-encapsulated folate-modified N-succinyl-N′-octyl chitosan micelles. J Pharm Sci. 2013, 102 (4):1318-1332.

19. Hongyan Zhu, Fei Liu, Jing Guo, Jianpeng Xue, Zhiyu Qian, Yueqing Gu*. Folate-modified chitosan micelles with enhanced tumor targeting evaluated by near infrared imaging system. Carbohydrate Polymers. 2011, 86(3):1118-1129.

20. Jie Cao#, Hongyan Zhu#, Dawei Deng, Bing Xue, Liping Tang, Didel Mahounga, Zhiyu Qian, Yueqing Gu*, In vivo NIR imaging with PbS quantum dots entrapped in biodegradable micelles. Journal of Biomedical Materials Research Part A. 2012: 100A: 958-968.

21. 程紫婷，姚珂，刘婉婉，许伯慧，朱红艳*,紫杉醇温敏脂质体与siRNA金纳米星载药系统的构建与表征.中国药科大学学报. 2017, 48(4):444-45.

22. 朱红艳, 朱景平, 谢爱梅, 袁静, 花烨, 张伟*.肿瘤靶向高分子碲化镉量子点复合纳米粒的制备及其表征.药学学报. 2014, 49 (10): 1457 -1465.

23. 刘婉婉，张胜喻，杨彧，朱红艳*.具有肿瘤靶向及穿膜效应的壳聚糖胶束的制备.中国药科大学学报. 2015, 46(5): 561-567.

24. 周瑶，曹欣雨，周佳敏，朱红艳*.口服维生素C脂质体的制备及其稳定性研究.南通大学学报（医学版）. 2020, 40(5): 1-3.

25. 发明专利：朱红艳,许伯慧,陈忠平.一种仿生siRNA胶束纳米复合物及应用.专利号：ZL 2015 1 0189351.6.

26. 朱红艳，赵刘碗，韩伟莉.复合siRNA纳米载体及其制备方法和应用.专利号：201810990330.8.

27. 已经转让的专利：朱红艳,谢爱梅,杨池,张贝贝,王逸飞.一种基于量子点的多功能纳米siRNA载体系统的制备及应用.专利号：ZL 2014 1 0087972.9，转让时间：2020年，转让经费：4万元.

28. 朱红艳,赵刘碗,韩伟莉.光热材料和外泌体介导的化疗药组成的药物及其用途, 2019.02.13, CN2019101129258.