药物制剂系

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朱红艳

作者:金飞     日期:2021-10-26   点击数:40  

师资介绍


朱红艳,女,汉族,1978年6月生,教授,博士,药剂系主任


研究方向:

1.核酸药物递释系统;2.基于外泌体的靶向递送。


主持或参加科研项目(课题):

  1. 1、江苏省自然科学基金面上项目,BK20201443,靶向调控肿瘤转移前微环境的工程化“外泌体影”仿生递释系统研究,2020/7-2023/610万元,在研,主持 ;

  2. 2、国家自然科学基金青年基金项目,81202467,胞内触发释药的仿生型siRNA自组装胶束纳米复合物的构建、抗肿瘤转移作用及细胞内药物动力学研究,2013/1-2015/1223万元,已结题,主持 ;

  3. 3、江苏省青年科学基金项目BK2012232靶向肿瘤血管生成的仿生型小核酸药物递释系统研究2012/7-2015/720万元,已结题,主持 ;

  4. 4、江苏省教育厅高校自然科学研究面上项目11KJB350004谷胱甘肽触发释放的智能型siRNA复合载体(穿膜肽Tat-壳聚糖-量子点)的构建及其抗肿瘤活性研究2011/01-2014/123万元,已结题,主持 ;

  5. 5、江苏省高校自然科学研究指导性项目06KJD310150南瓜多糖对链脲菌素诱导的胰岛损伤的保护作用及机制研究2007/01-2008/121万元,已结题,主持。

  6. 6、南通市课题,Exosome@CBSA 仿生 siRNA 递送系统的构建及其抗乳腺癌术后转移作用研究,2018.07-2020.06,项目编号:JC20180245万元。


    代表性研究成果和学术奖励情况:

第一作者和通讯作者论文,专利

  1. 1.Shengyu Zhang, Ye Gan, Lanlan Shao, Tianqing Liu, Danyi Wei, Yanyan Yu,* Hongwei Guo,* and Hongyan Zhu*. Virus Mimetic Shell-Sheddable Chitosan Micelles for siVEGF Delivery and FRET-Traceable Acid-Triggered Release. ACS Appl. Mater. Interfaces. 2020, 12, 53598−53614.IF=9.229

  2. 2.LiuwanZhao, ChunyanGu, YeGan, LanlanShao, HongweiChen, HongyanZhu*. Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis. JControl Release.2020, 318, 1-15.IF=9.776

  3. 3.Hongyan Zhu,Weili Han, Ye Gan, Qiaofeng Li, Xiaolan Li, Lanlan Shao, Dan Zhu* andHongwei Guo*. Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma. Pharmaceutics 2019, 11(12), 683IF=6.321

  4. 4.Yanyan Yu, Min Zhou, Wei Zhang, Lei Huang, Dandan Miao, Hongyan Zhu*, Gaoxing Su*. Rattle-Type Gold Nanorods/Porous-SiO2 Nanocomposites as Near-Infrared Light-Activated Drug Delivery Systems for Cancer Combined Chemo-Photothermal Therapy.Mol. Pharmaceutics. 2019,16(5) 1929-1938IF=4.939

  5. 5.Su GMiao DYu YZhou MJiao PCao XYan BZhu H*.Mesoporous silica-coated gold nanostars with drug payload for combined chemo-photothermal cancer therapy. J Drug Target. 2019 Feb;27(2):201-210. IF=5.121

  6. 6.ShengyuZhang, YanjunLiu, YeGan, NanqingQiu, YueqingGuHongyan Zhu*. Conjugates of TAT and folate with DOX-loaded chitosan micelles offer effective intracellular delivery ability.Pharm Dev Technol. 2019, 24(2):253-261.IF=3.133

  7. 7.Shengyu Zhang, Liuwan Zhao, Nanqin Qiu, Yanjun Liu, Bohui Xu, Hongyan Zhu*, On the hypoxic tumor targeting ability of twochitosan micelles loaded with oil-soluble CdSequantum dots. Pharm Dev Technol. 2018, 23(1):87-95.IF=3.133

  8. 8.Hongyan Zhu*, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu and Gaoxing Su*, Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment. Int J Mol Sci. 2017, 18(10):2029.IF=5.923

  9. 9.Fei Liu, Yuan Sun, Chen Kang, Hongyan Zhu*. Pegylated drug delivery systems: from design to biomedical applications. Nano Life. 2016, 6(3, 4):1642002 (1-11).

  10. 10.Bohui Xu, Yubin Wang, Hongyan Zhu*. Mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: Preparation and pharmacokinetics in beagle dogs. Pharmazie. 2016 71(2):76-83. IF=1.267

  11. 11.Hongyan Zhu, Shengyu Zhang, Yongling, Guoliang Meng, Yu Yang, Wei Zhang*. pH-responsive hybrid quantum dots for targeting hypoxic tumor siRNA delivery. JControl Release. 2015, 220(Pt A):529-544. IF=9.776

  12. 12.Hongyan Zhu, Guangtong Chen, Guoliang Meng Jiliang Xu*. Characterization of pumpkin polysaccharides and protective effects on streptozotocin-damaged islet cells. Chin J Nat Med. 2015, 13(3):199-207. IF=3.000

  13. 13.Hongyan Zhu, JingPing Zhu, AiMei Xie, Yong Lin, BeiBei Zhang, YiFei Wang, Wei Zhang*.Visible quantum-dot-based targeted siRNA delivery for HIF-1α gene silencing. J. Drug Del. Sci. Tech. 2014, 24 (5): 445-451.IF=3.981

  14. 14.Hongyan Zhu, Jie Cao, Sisi Cui, Zhiyu Qian, Yueqing Gu*. Enhanced tumor targeting and antitumor efficacy via hydroxycamptothecin-encapsulated folate-modified N-succinyl-N-octyl chitosan micelles. J Pharm Sci. 2013, 102 (4):1318-1332. IF=3.534

  15. 15.Hongyan Zhu, Fei Liu, Jing Guo, Jianpeng Xue, Zhiyu Qian, Yueqing Gu*. Folate-modified chitosan micelles with enhanced tumor targeting evaluated by near infrared imaging system. Carbohydrate Polymers. 2011, 86(3):1118-1129. IF=9.381

  16. 16.Jie Cao#, Hongyan Zhu#, Dawei Deng, Bing Xue, Liping Tang, Didel Mahounga, Zhiyu Qian, Yueqing Gu*, In vivo NIR imaging with PbS quantum dots entrapped in biodegradable micelles. Journal of Biomedical Materials Research Part A. 2012: 100A: 958-968. IF=4.396

  17. 17.程紫婷,姚珂,刘婉婉,许伯慧,朱红艳*, 紫杉醇温敏脂质体siRNA金纳米星载药系统的构建与表征.中国药科大学学报. 2017, 48(4):444-45.

  18. 18.朱红艳,  朱景平,  谢爱梅,  袁静,  花烨,  张伟*. 肿瘤靶向高分子碲化镉量子点复合纳米粒的制备及其表征. 药学学报. 2014, 49 (10): 1457 -1465.

  19. 19.刘婉婉,张胜喻,杨彧,朱红艳*. 具有肿瘤靶向及穿膜效应的壳聚糖胶束的制备. 中国药科大学学报. 2015, 46(5): 561-567.

  20. 20.周瑶,曹欣雨,周佳敏,朱红艳*. 口服维生素C脂质体的制备及其稳定性研究. 南通大学学报(医学版). 2020, 40(5): 1-3.

  21. 21.发明专利:朱红艳, 许伯慧, 陈忠平. 一种仿生siRNA胶束纳米复合物及应用. 专利ZL 2015 1 0189351.6,授权日:2018.07.24.

  22. 22.发明专利:朱红艳, 谢爱梅, 杨池, 张贝贝, 王逸飞. 一种基于量子点的多功能纳米siRNA载体系统的制备及应用. 专利ZL 2014 1 0087972.9,授权日:2017.05.17.

  23. 23.朱红艳,赵刘婉,韩伟莉. 复合siRNA纳米载体及其制备方法和应用. 申请号:2018109903308,实审发文号:2019010700540360.

  24. 24.光热材料和外泌体介导的化疗药组成的药物及其用途. 申请号:2019101129258, 实审发文号:2019042800173150.