陆春风
师资介绍
陆春风,男,汉族,1989年2月生,博士,副教授,硕士生导师。
教育经历:
2008.09-2012.06南京中医药大学,药学,学士
2012.09-2017.06南京中医药大学,中药学,博士
工作经历:
2019.02-2020.02美国路易斯安那州立健康科学中心,眼科学,博士后
2018.12-2022.08南通大学,药学院,讲师
2022.09-至今 南通大学,药学院,副教授
研究方向:
肝脏疾病及药物防治
基金项目:
国家自然科学基金委员会,青年项目,81803606,川芎嗪通过Sestrin2调控自噬介导的肝细胞程序性坏死防治酒精性肝病的机制研究,2019-01至2021-12,21万元,结题,主持。
江苏省高等学校自然科学研究项目,22KJB360015,基于UQCRC2介导自噬探究紫檀芪抑制酒精性肝细胞衰老的机制,2022-07至2024-06,3万元,在研,主持。
南通市科学计划项目,MS12018051,Nrf2/HMGB1轴调控细胞程序性坏死在奥沙利铂致肝毒性中的作用及临床意义,2018-07至2020-06,10万元,结题,主持。
代表性论文:
Cai Y, Wang Y, Su W, Zhou X,Lu C(通讯作者). Angelica sinensis polysaccharide suppresses the Wnt/β-catenin-mediated malignant biological behaviors of breast cancer cells via the miR-3187-3p/PCDH10 axis. Biochem Pharmacol. 2024 Jul;225:116295.(二区)
Ge T, Shao Y, Bao X, Xu W,Lu C(通讯作者). Cellular senescence in liver diseases: From mechanisms to therapies. Int Immunopharmacol. 2023 Aug;121:110522.(二区)
Jiang Y, Zhou Y, Xu W, Wang X, Jin H, Bao X,Lu C(通讯作者). Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy. Cell Biol Toxicol. 2023 Jun;39(3):729-749.(二区)
Lu C(第一作者), Jiang Y, Xu W, Bao X. Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases. Cell Death Dis. 2023 Feb 25;14(2):160.(一区)
Lu C(第一作者), Ge T, Shao Y, Cui W, Li Z, Xu W, Bao X. ZNF281 drives hepatocyte senescence in alcoholic liver disease by reducing HK2-stabilized PINK1/Parkin-mediated mitophagy. Cell Prolif. 2023 Mar;56(3):e13378.(一区)
Zhou Y, Wu R, Wang X, Bao X,Lu C(通讯作者). Roles of necroptosis in alcoholic liver disease and hepatic pathogenesis. Cell Prolif. 2022 Mar;55(3):e13193.(一区)
Zhou Y, Wu R, Wang X, Jiang Y, Xu W, Shao Y, Yue C, Shi W, Jin H, Ge T, Bao X,Lu C(通讯作者). Activation of UQCRC2-dependent mitophagy by tetramethylpyrazine inhibits MLKL-mediated hepatocyte necroptosis in alcoholic liver disease. Free Radic Biol Med. 2022 Feb 1;179:301-316.(一区)
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C(通讯作者). Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation. Toxicology. 2021 Sep;461:152923.(三区)
Wu R, Wang X, Shao Y, Jiang Y, Zhou Y,Lu C(通讯作者). NFATc4 mediates ethanol-triggered hepatocyte senescence. Toxicol Lett. 2021 Oct 10;350:10-21.(三区)
Zhou Y, Jin H, Wu Y, Chen L, Bao X,Lu C(通讯作者). Gallic acid protects against ethanol-induced hepatocyte necroptosis via an NRF2-dependent mechanism. Toxicol In Vitro. 2019 Jun;57:226-232.(三区)