基础药理系

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张小玲

作者:金飞     日期:2021-10-26   点击数:96  

师资介绍



张小玲,女,汉族,198912月生,讲师,博士


研究方向:

抗帕金森病中药有效成分及分子机制研究


基金项目:

  1. 国家自然科学基金青年项目:基于CacyBP/SIP介导的α-synuclein自噬降解调控探讨虫草素对帕金森病早期嗅觉障碍的干预及其机制研究 (2022/01-2024/12, 24万元,8210141560),在研,张小玲,负责人

  2. 江苏省自然科学基金青年项目。知母宁基于SBP1/GPX1通路在肝纤维化上皮细胞-间充质转化中的作用及机制研究(2019/06-2022/0620万元,BK20190909),在研张小玲,负责人。

  3. 天然药物活性物质与功能国家重点实验室项目:壮药鸡血藤活性成分刺芒柄花素靶向SBP1介导EMT抗肝纤维化作用及机制研究(2020.1-2021.129万,GTZK202008),在研张小玲,负责人。

  4. 江苏省高层次创新创业人才引进计划资助项目-江苏省双创博士人才项目。2019/06-2022/0615万)。张小玲,负责人

  5. 扬州市绿杨金凤人才项目。2020/01-2021/126万)。张小玲,负责人。

科研成果:

代表性论文

1 Xiaoling Zhang, Lina Xu, Lianhong Yin, et al. Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats. Chemical Communications, 2015, 51 (55):  11604-11607. (IF: 6.567). 

2 Xiaoling Zhang, Xu Han, Lianhong Yin, et al. Potent effects of dioscin against liver fibrosis. Scientific Reports, 2015, 5: 9713. (IF: 5.228).

Xiaoling Zhang, Youwei Xu, Yan Qi, et al. Potent effects of dioscin against thioacetamide-induced liver fibrosis through attenuating oxidative stress in turn inhibiting inflammation, TGF-β/Smad and MAPK signaling pathways. Journal of Functional Foods, 2015, 16: 436-447. (IF: 3.973).

4 Xiaoling Zhang, Yuhe Yuan,Qianhang Shao, et al. DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult.Toxicology Letters,2017, 271:74-83. (IF: 3.858).

5 Xiaoling Zhang, Zhenzhen Wang,Qianhang Shao, et al.RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells. Brain research bulletin. 2019, 146:228-236. (IF: 3.44).

6 Xiaoling Zhang, Wenmin Huanga, Yiyun Fan, et al. Role of GTPases in the regulation of mitochondrial dynamics in Parkinson's disease.Experimental Cell Research. 2019,382: 111460. (IF: 3.3).

7 Xiaoling Zhang, Wenmin Huanga, Qianhang Shao, et al. Drp1, a potential therapeutic target for Parkinson's disease, is involved in olfactory bulb pathological alteration in the Rotenone-induced rat model. Toxicology Letters. 2020, 325, 1-13. (IF: 3.569).

8 Xiaoling Zhang, Wenmin Huang, Ying Sun, et al. Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission. Neurotoxicology. 2021, 84: 1-13. (IF: 3.148).

9 Ying Sun, Wenmin Huang, Peichen Tang, Xin Zhang, Xiaoyan Zhang, Bocheng Yu, YiYun Fan, Xiaoqun Ge*, Xiaoling Zhang**.Neuroprotective effects of natural cordycepin on LPS-induced Parkinson’s disease through suppressing TLR4/NF-κB/NLRP3-mediated pyroptosis. Journal of Functional Foods. 202075: 104274  (IF: 3.701)

10 Xiaoling Zhang*, Xiaoyan Zhang, Wenmin Huang, et al. The role of heat shock proteins in the regulation of fibrotic diseases. Biomedicine & Pharmacotherapy. 135 (2021) 111067(IF:4.4)

11 张小玲, 王真真, 温路等. 细胞因子与抑郁症关系的研究进展.神经药理学报,2016, 6:31-36.