陆需

师资介绍

陆需，女，汉族，1989年5月生，博士，讲师。

教育经历：

2007.09-2011.06南京中医药大学，药学，学士

2013.09-2016.06南通大学，药理学，硕士

2016.07-2019.03日本东北医科药科大学，药科学，博士

工作经历：

2019.04-至今 南通大学，药学院，讲师

研究方向：

神经精神药理学，神经免疫药理学

基金项目：

1. 江苏省教育厅，面上项目，23KJB310020，皮质醇异常环境下Phox2b介导USP4转录进而稳定DNMT1参与抑郁症发生的机制研究，2023-07至2025-07，3万元，在研，主持

2. 江苏省教育厅，面上项目，20KJB310025，组蛋白去甲基化酶PHF2通过CREB调控抑郁症发生的机制研究，2020-12至2022-12，3万元，结题，主持

3. 南通市科技计划项目，JC2020020，Skp2通过海马PPARα调控抑郁症发生的分子机制，2020-10至2022-09，3万元，结题，主持

4. 国家自然科学基金委员会，面上项目，82371519，FBXL19与USP14双向调节室旁核CBP稳定在慢性应激致HPA轴亢奋进程中的效应研究，2024-01-01至2027-12-31，47万元，在研，参与

5. 江苏省自然科学基金面上项目，BK20221375，SENP3介导海马法尼醇X受体（FXR）去SUMO化修饰参与抑郁症发生的机制研究，2022-07至2025-06，10万元，在研，参与

6. 国家自然科学基金委员会，面上项目，82071519，室旁核QRFP-GPR103系统调控HPA轴亢奋在抑郁症发病机理中的作用研究，2021-01-01至2024-12-31，55万元，在研，参与

科研成果：

近5年侧重于抑郁症、焦虑症、创伤后应激障碍等情绪障碍疾病研究。所在课题组主要应用分子生物学、组织与细胞形态学、神经化学与药理学、基因干预与行为学等多学科交叉策略研究核受体、脑源性生长因子信号及外周/中枢免疫炎症反应与抑郁症、焦虑症、创伤后应激障碍等情绪障碍疾病的关系，着力探讨预防和治疗情绪障碍疾病的潜在药物和特异性生物学靶标。

近五年来，在Brain Behavior and Immunity、International Immunopharmacology、Neuropharmacology、International Journal of Neuropsychopharmacology、Journal of Neuroinflammation、European Journal of Pharmacology等杂志上发表神经精神领域SCI论文31篇。

成果奖励：

1、江苏省药理科学技术进步奖，靶向小胶质细胞的抑郁症发病机制及治疗策略研究，二等奖2/3

2、江苏省高等学校科学技术研究成果奖，靶向小胶质细胞的抑郁症发病机制及防治策略研究，三等奖2/3

代表性论文：

1. Lu X^#, Liu H^#, Cai Z^#, Hu Z^#, Ye M, Gu Y, Wang Y, Wang D, Lu Q, Shen Z, Shen X, Huang C^*. ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation.Brain Behav Immun. 2022, 106:147–160.

2. Hu Z^#, Gu Y^#, Ye M^#, Ma Y, Wang Y, Pan S, Huang C^*,Lu X^*. Innate immune stimulation prevents chronic stress-induced depressive and anxiogenic-like behaviors in female mice.Int Immunopharmacol. 2022, 111:109126.

3. Tan P^#, Xue T^#, Wang Y^#, Hu Z^#, Su J^#, Yang R, Ji J, Ye M, Chen Z, Huang C^*,Lu X^*. Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the development of depression-like behaviors in mice. Neuropharmacology. 2022, 17:108990.

4. Gu Y^#, Ye T^#, Tan P^#, Tong L^#, Ji J, Gu Y, Shen Z, Shen X,Lu X^*,Huang C^*.Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice.Brain Behav Immun. 2021, 91:451–471.

5. Lu X, Zhang D, Shoji H, Duan C, Zhang G, Isaji T, Wang Y, Fukuda T^*, Gu J^*. Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators.Biochim Biophys Acta Gen Subj. 2019, 1863(3):598-608.

6. Ren J^#, Zhang Y^#, Pan H^#, Shi R^#, Zhu H^#, Yang R, Zhang L, Chen B, Zhu T, Lu X^*, Huang C^*. Mobilization of the innate immune response by a specific immunostimulant β-glucan confers resistance to chronic stress-induced depression-like behavior by preventing neuroinflammatory responses. Int Immunopharmacol. 2024, 127:111405.

7. Zhao C^#*, Shi R^#,Lu X^#, Yang R^#, Chen Z^#, Chen B, Hu W, Ren J, Peng J, Zhu T, Zhu H, Huang C^*. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. Eur J Pharmacol. 2024, 964:176288.

8. Zhao C^#*, Chen Z^#,Lu X^#, Hu W^#, Yang R^#, Lu Q, Chen B, Huang C^*. Microglia-Dependent Reversal of Depression-Like Behaviors in Chronically Stressed Mice by Administration of a Specific Immuno-stimulant β-Glucan. Neurochem Res. 2024, 49(2):519-531.

9. Chen B^#, Zhao C^#, Zhu H^#,Lu X^#, Liu H, Lu Q, Zhu T, Huang C^*. β-glucan, a specific immuno-stimulant, produces rapid antidepressant effects by stimulating ERK1/2-dependent synthesis of BDNF in the hippocampus. Eur J Pharmacol. 2023, 961:176161.

10. Ni M^#, Zheng M^#, Chen B^#, Lu X^#, Zhao H, Zhu T, Cheng L, Han H, Ye T, Liu H, Ye Y, Huang C^*, Yuan X^*. Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. Neuropharmacology. 2023, 240:109693.

11. Ye M^#, Xiang H^#, Liu H, Hu Z, Wang Y, Gu Y,Lu X^*, Huang C^*. Innate immune tolerance against adolescent intermittent alcohol exposure-induced behavioral abnormalities in adult mice. Int Immunopharmacol. 2022, 113(Pt A):109250.

12. Shi R^#, Liu H^#, Tan P^#, Hu Z^#, Ma Y^#, Ye M, Gu Y, Wang Y, Ye T, Gu Y,Lu X^*, Huang C^*. Innate immune stimulation prevents the development of anxiety-like behaviors in chronically stressed mice. Neuropharmacology.2022, 207:108950.

13. Li F^#,Lu X^#, Ma Y^#, Gu Y^#, Ye T, Huang C^*. Monophosphoryl lipid A tolerance against chronic stress-induced depression-like behaviors in mice. Int J Neuropsychopharmacol. 2022, 7:pyab097.

14. Li F^#, Xiang H^#, Gu Y, Ye T,Lu X^*, Huang C^*. Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice. J Neuroinflammation. 2022, 19(1):12.

15. Lu Q^#, Xiang H^#, Zhu H, Chen Y,Lu X^*, Huang C^*. Intranasal lipopolysaccharide administration prevents chronic stress-induced depression- and anxiety-like behaviors in mice. Neuropharmacology.2021, 200:108816.

16. Ji J^#, Xiang H^#,Lu X^#, Tan P^#, Yang R^#, Ye T, Chen Z, Chen D, He H, Chen J, Ma Y^*, Huang C^*. A prophylactic effect of macrophage-colony stimulating factor on chronic stress-induced depression-like behaviors in mice. Neuropharmacology. 2021, 193:108621.

17. Li F^#, Huang C^#,Lu X^#, Xiang H^#, Wang D, Chen Z, Chen J, He H, Yuan X^*. Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice. Behav Pharmacol. 2021, 32(1):62-72.