刘昕

师资介绍

刘昕，男，汉族，1987年8月生，博士，副教授，硕士生导师。入选2020年江苏省双创博士。

教育经历：

2017年9月毕业于南京大学化学专业，获理学博士学位。

工作经历：

2018.09-2022.10南通大学，药学院，讲师

2022.10-至今 南通大学，药学院，副教授教授

研究方向：

超分子药物化学，智能纳米药物载体和纳米反应器构建，超分子动态材料

基金项目：

1. 国家自然科学基金青年项目，22001133，超分子级联纳米反应器的构筑及其用于缺氧肿瘤诊断与多模式协同治疗，2021/01-2023/12，30万元，已结题，主持

2. 南通市科技项目，JC2020075，肿瘤微环境激活的的超分子级联纳米反应器，2020/10-2022/9，3万元，已结题，主持

3. 南通大学人才引进项目，水溶性柱芳烃与人胰岛素的主-客体化学研究及在糖尿病治疗中的应用，2019/05-2022/05，8万元，已结题，主持

科研成果：

课题组主要基于超分子自组装实现新型功能材料、智能纳米载体和纳米反应器的高效构建，并探究其在肿瘤、炎症、糖尿病等疾病中的治疗和诊断作用和机制。以第一作者/通讯作者在ACS Applied Materials & Interfaces、Chemistry of Materials、Journal of Colloid and Interfaces Science、Chinese Chemical Letters、Chemical Communications等国际知名期刊上发表论文多篇。

代表性论文：

1. Xin Liu*, Ji Liu, Qin Xu, Weizhi Tao, Xudong Xie, Chi Meng, Qinbei Zhou, Yanan Zhang, Yong Ling*. A versatile supramolecular nanoagent for three-pronged boosting chemodynamic therapy, J. Colloid Interface Sci., 2023, 648, 994-1005.

2. Chi Meng, Xudong Xie, Jianqiang Qian, Weizhi Tao, Hongmei Wu, Dongliang Ji, Ge Gao, Ruojia Wang, Changchun Ling, Yanan Zhang,Xin Liu*, Yong Ling*. TME-targeting nano-theranostic agent for NIR fluorescence diagnosis and O2-economized PDT-based multimodal synergistic therapy. Mater. Des., 2023, 233, 112251.

3. Xin Liu*, Ji Liu, Chi Meng, Peng Zhu, Xiao Liu, Jianqiang Qian, Shijia Ling, Yanan Zhang, Yong Ling*. Pillar[6]arene-based supramolecular nanocatalysts for synergistically enhanced chemodynamic therapy by the intracellular cascade reaction. ACS Appl. Mater. Interfaces, 2021, 13, 53574-53585.

4. Xin Liu*, Chi Meng, Guiqing Ji, Ji Liu, Peng Zhu, Jianqiang Qian, Shun-Xing Zhu, Yanan Zhang, Yong Ling*. Tumor microenvironment-activatable Boolean logic supramolecular nanotheranostics based on a pillar[6]arene for tumor hypoxia imaging and multimodal synergistic therapy, Mater. Chem. Front., 2021, 5, 5846.

5. Peng Zhu, Weidan Luo, Jianqiang Qian, Chi Meng, Wenpei Shan, Zhongyuan Xu, Wei Zhang,Xin Liu*, Yong Ling*. GSH/ROS dual-responsive supramolecular nanoparticles based on pillar[6]arene and betulinic acid prodrug for chemo–chemodynamic combination therapy, Molecules, 2021, 26, 6900.

6. Xin Liu, Kaiya Wang, Marlen Externbrink, Jochen Niemeyer, Michael Giese, Xiao-Yu Hu*. Control of secondary structure and morphology of peptide– guanidiniocarbonylpyrrole conjugates by variation of the chain length, Chin. Chem. Lett., 2020, 31, 1239-1242.

7. Ji Liu,#Xin Liu,# Jianqiang Qian, Chi Meng, Peng Zhu, Jiaying Hang, Yaling Wang, Biao Xiong, Xiaodong Qiu, Weizhong Zhu, Yumin Yang, Yanan Zhang,* and Yong Ling*. Development of pH/Glutathione-Responsive Theranostic Agents Activated by Glutathione S Transferase π for Human Colon Cancer, J. Med. Chem. 2020, 63, 9271−9283.