黄海琴
师资介绍
黄海琴，女，汉族，1987年11月生，博士，讲师，硕士生导师。
教育经历：
2006.09-2000.07中国药科大学，药学院，药物制剂，学士
2010.09-2013.07中国药科大学，药学院，药剂学，硕士
2016.09-2020.06中国药科大学，药学院，药剂学，博士
工作经历：
2013/07-2016/08，江苏奥赛康药业股份有限公司，靶向制剂研究所，制剂研究员
2020/09-至今，南通大学，药学院，讲师
研究方向：
缓控释制剂的研究与开发；药物递送
基金项目：
1.国家自然科学基金青年基金项目，82104088，巨噬细胞脂质代谢驱动的胞内外递送统的构建及在动脉粥样硬化治疗中的应用研究，2022/1-2014/12，30万元，在研，主持
2.国家重点基础研究发展计划，973计划，基于释药动力学的非晶态给药体系的评价方法研究，2012CB724002，2011/01至2014/12，50万，结题，参与。
代表性论文与成果：
Xinyu Cao, Bingyu Wu, Jiayi Chen, Zhikuan Liu, Yang Yang, Shanshan Li, Hongyan Zhu, Lixing Xu,Haiqing Huang. Hydroxypropyl Cellulose-Based Orally Dissolving Film Loaded with Insoluble Dexamethasone for Treatment of Oral Ulcers, Molecular Pharmaceutics, 2024,21,8,4012-4023.
Liqiao Zhang, Xinyu Cao, Jiayi Chen, Yanyan Dong, Wenwen Chen, Yu Gao, Jingjing Guo,Haiqin Huang. Co-delivery of siBcl-2 and PTX with mitochondria-targeted functions to overcoming multidrug resistance, International Journal of Pharmaceutics, 2024, Apr 10:654:123970.
Dan Sun, Xiao Du, Xinyu Cao, Bingyu Wu, Shanshan Li, Yongmei Zhao, Tianqing Liu, Lixing Xu,Haiqin Huang. Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells, Molecular Pharmaceutics, 2024 Apr 1;21(4):2043-2057.
Lixing Xu, Xiao Du, Yao Zhou, Xinyu Cao, Ying Shen, Hongyan Zhu,Haiqin Huang.
Polyaspartic Acid-Stabilized CaCO3-Containing In Situ Hydrogel for Protection and Treatment of Gastric Ulcer, Molecular Pharmaceutics, 2023 Apr3;20(4):2105-2118.
Lixing Xu, Enhe Bai, Yangbo Zhu, Jiayi Qin, Xiao Du,Haiqin Huang. pH-Responsive Hydrogel as a Potential Oral Delivery System of Baicalin for Prolonging Gastroprotective Activity, Pharmaceutics, 2023, Jan 11; 15(1):257.
Haiqin Huang, Lanlan Shao, Yan Chen, Weili Han, Yao Zhou, Tianqing Liu, Jinhua Gu, Hongyan Zhu. Sequential Dual Delivery System Based on siCOX-2-Loaded Gold Nanostar and Thermal-Sensitive Liposomes Overcome Hypoxia-Mediated Multidrug Resistance in Tumors, 2022 Jul 4; 19(7): 2390-2405.
Haiqin Huang, Lanlan Shao, Yan Chen, Lan Tang, Tianqing Liu, Junxu Li, Hongyan Zhu. Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer, Bioengineering&Translational Medicine,2021, e10284.
Haiqin Huang, Kang Sha, Hanitrarimalala Veroniaina, Ziheng Wu, Zhenghong Wu*, Xiaole Qi*. Ca2+ participating self-assembly of an apoferritin nanostructure for nucleic acid drug delivery, Nanoscale, 2020(12):7347-7358.
Haiqin Huang, Shirui Yuan, Zhuo Ma, Peng Ji, Xiaonan Ma, Zhenghong Wu*, Xiaole Qi*. Genetic recombination of poly(L-lysine) functionalized apoferritin nanocages that resemble viral capsid nanometer-sized platforms for gene therapy. Biomaterials Science, 2020(8): 1759-1770.
Haiqin Huang, Xiaole Qi, Yanhua Chen*, Zhenghong Wu*. Thermo-sensitive hydrogels for delivering biotherapeutic molecules: A review, Saudi Pharmaceutical Journal, 2019, 2019(27): 990-999.
Haiqin Huang, Zhenghong Wu*, Xiaole Qi*, Huiting Zhang, Qin Chen, Jiayu Xing, Haiyan Chen, Yao Rui. Compression-coated tablets of glipizide using hydroxypropylcellulose for zero-order release: In vitro and in vivo evaluation, International Journal of Pharmaceutics, 2013, 2013(446): 211-218.
Liqiao Zhang, Xiuhua Pan, Lixing Xu, Linlin Zhang*,Haiqin Huang*. Mitochondria-targeted curcumin loaded CTPP–PEG–PCL self-assembled micelles for improving liver fibrosis therapy. RSC advances, 2021,11,5348.
Peng Ji,Haiqin Huang, Shirui Yuan, Le Wang, Siqi Wang, Yiwei Chen, Na Feng, Hanitrarimalala Veroniaina, Ziheng Wu, Zhenghong Wu*, Xiaole Qi*. ROS-Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide-Containing Recombinant Apoferritin. Advanced Healthcare Materials, 2019(8).
发明专利:siRNA-生物钙化重组去铁蛋白纳米粒及其制备方法.专利授权号：CN110075087B,授权日：2021年3月16日。
江苏省高等学校重点教材、全国高等教育药学类规划教材《药物制剂工程学》，化学工业出版社，2022，参编。
《工业药剂学学习指导》用书，化学工业出版社，2023，副主编。