王开开
师资介绍
王开开，男，汉族，1985年12月生，博士，副教授，硕士生导师。
教育经历：
2004.09-2009.06南京工业大学，药物制剂，学士
2009.09-2015.09 南京大学，药学，博士
工作经历：
2015.12-2018.07中国药科大学，药学，博士后（Prof. David Oupicky）
2018.07-至今 南通大学，药学院，副教授
研究方向：
药物递送，纳米医学
基金项目：
国家青年自然科学基金，81202474 “气管味蕾”探索苦味淬灭的规律,2013/01-2015/12参与
国家自然科学基金面上项目，81473146、可示踪可激发体内双级递氧体系构建与评价、2015/01-2018/12、70万元、参与。
中国博士后基金面上项目，2016M601923、具有靶向和促释双功能纳米递药系统的研究、2016/11-2018/6、5万元、结题，主持。
江苏省高等学校自然科学基金，深层次递氧氟化纳米粒用于肿瘤的光动力免疫协同治疗、2019/9-2021.8、5万 主持
国家自然科学青年基金，多级可控深层次递氧纳米制剂用于肿瘤的光动力免疫协同治疗、2020/1-2022/12、20万 主持
2020年江苏省双创博士，15万 主持
科研成果：
主要研究方向为纳米制剂在人体界面屏障中的动力学规律，并致力于理解药剂学的基本原理，运用多学科手段尝试解决药剂学中存在的基本问题。申请专利多项，授权一项。已发表SCI论文五十余篇，引用超二千六百次，其中第一作者和通讯作者论文累计超过20篇，包括Journal of Nanobiotechnology, ACS Applied Materials & Interfaces, Nanomedicine, Science China Materials等杂志。担任Advanced Science, Chemical Engineering Journal, International Journal of Pharmaceutics等多家SCI杂志审稿人。主持多项基金，包括中国博士后基金，国家自然科学青年基金，江苏省高校自然科学基金以及江苏省双创博士等。获得南通大学优秀本科论文指导老师（2020年），指导学生获得江苏省本科毕业论文一等奖（2021年），参与获得教育部高等学校自然科学优秀成果一等奖。任中国民族医药学会方药量效研究分会理事，南通市药师协会常务理事等
代表性论文：
1, Wang, H., Yang, Y., Xu, Y., Chen, Y., Zhang, W., Liu, T., Chen, G&Wang, K. (2024). Phage-based delivery systems: engineering, applications, and challenges in nanomedicines. Journal of Nanobiotechnology, 22(1), 365.
2, Ding, K., Li, H., Xu, Q., Zhao, Y.,Wang, K., & Liu, T. (2024). Real-time label-free three-dimensional invasion assay for anti-metastatic drug screening using impedance sensing. Frontiers in Pharmacology, 15, 1387949.
3, Huan, X., Chen, Y., Wu, X., Wang, H., Yang, Y., Wu, P.,Wang, K.* & Ding, D.* (2023). Balancing and Therapeutic Roles of CXCR4‐Inhibiting Nanomedicine via Synergetic Regulation of Hepatic Stellate Cells and Extracellular Matrix in Liver Injury. Chinese Journal of Chemistry, 41(24), 3669-3676.
4, Zhang, J., Wang, M., He, D., Zhang, L., Liu, T. *, &Wang, K.* (2023). Synergetic regulation of cancer cells and exhausted T cells to fight cold tumors with a fluorinated EGCG-based nanocomplex. Journal of Nanobiotechnology, 21(1), 420.
5. Gong G, Qian W, Zhang L, Jia J, Xie J, Zhu Q, Liu W, Tu P, Gao M, Zhang L, Tang H, Su H, Wei K*, Zhou C*,Wang K*, Pan Q*. A curcumin-induced assembly of a transferrin nanocarrier system and its antitumor effect. Colloids Surf B Biointerfaces. 2022 Sep;217:112613.
6. Fu Z, Wang X, Lu X, Yang Y, Zhao L, Zhou L,Wang K*, Fu H*. Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy. Front Bioeng Biotechnol. 2022 Aug 15;10:962380.
7, Wu, P., Jiang, X., Yin, S., Yang, Y., &Wang, K.*. (2021). Biomimetic recombinant of red blood cell membranes for improved photothermal therapy. Journal of Nanobiotechnology, 19(1).
8, Chen, G., Ullah, A., Xu, G., Xu, Z., Wang, F., Liu, T.,Wang, K.* (2021). Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy. Drug delivery, 28(1), 1923-1931.
9, Wu, P., Yin, S., Liu, T., Ding, D*., &Wang, K*. (2021). “Building-block crosslinking” micelles for enhancing cellular transfection of biocompatible polycations. Science China Materials, 64(1), 241-251.
10, Chen, G., Zhao, Y., Xu, Y., Zhu, C., Liu, T*., &Wang, K*. (2020). Chitosan nanoparticles for oral photothermally enhanced photodynamic therapy of colon cancer. International Journal of Pharmaceutics, 589, 119763
11,Wang, K, Chen, G, Q. Hu, Y. Zhen, H. Li, J. Chen, B. Di, Y. Hu, M. Sun, D. Oupicky. Self-assembled hemoglobin nanoparticles for improved oral photosensitizer delivery and photothermal therapy in vivo.Nanomedicine, 2017, 12 (9) :1043-1055.
12, Chen, G,Wang, K,* (共一及共同通讯作者), Zhou, Y., Ding, L., Ullah, A., Hu, Q., Sun, M* & Oupický, D*. (2016). Oral Nanostructured Lipid Carriers Loaded with Near-Infrared Dye for Image-Guided Photothermal Therapy.ACS Applied Materials & Interfaces, 8(38), 25087-25095.
13,Wang, K., Wang, J., Hu, W., Zhang, Y., Zhi, F., Zhou, Z., Wu, J & Hu, Y. (2015). Acid Denaturation Inducing Self-Assembly of Curcumin-Loaded Hemoglobin Nanoparticles. Materials, 8(12), 8701-8713.
14,Wang, K., Zhang, Y., Wang, J., Yuan, A., Sun, M., Wu, J., & Hu, Y. (2016). Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy.Scientific reports, 6, 27421.
15, Wang, K., Yuan, A., Yu, J., Wu, J., & Hu, Y. (2016). One-step self-assembling method to prepare dual-functional transferrin nanoparticles for antitumor drug delivery.Journal of pharmaceutical sciences, 105(3), 1269-1276.
16,Chen, G., Ding, L., Wu, P., Zhou, Y., Sun, M.,Wang, K*,(共同通讯作者) & Oupický, D*. (2018). Polymeric micelleplexes for improved photothermal endosomal escape and delivery of siRNA.Polymers for Advanced Technologies, 29(10), 2593-2600.
17, Sun M,Wang K, Oupický D. Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids [J].Advanced healthcare materials, 2018, 7(4): 1701070.
18, Chen, G.,Wang, K. (共一), Hu, Q., Ding, L., Yu, F., Zhou, Z., Sun, M. & Oupický, D. Combining Fluorination and Bioreducibility for Improved siRNA Polyplex Delivery.ACS Applied Materials & Interfaces. 2017, 9(5): 4457-4466.
19, Zhao, Y., Chen, G., Meng, Z., Gong, G., Zhao, W.,Wang, K.*, & Liu, T. (2019). A novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy.Drug Delivery, 26(1), 717-723.
20, Chen, G., Xu, Y., Wu, P., &Wang, K.* (2020). Self-assembled PEI nanomicelles with a fluorinated core for improved siRNA delivery.Journal of Drug Delivery Science and Technology,55, 101403.
21, Zhu, G.,Wang, K. (共一), Qin, H., Zhao, X., Chen, W., Xu, L., Guo, H. (2020). Internal cross-linked polymeric nanoparticles with dual sensitivity for combination therapy of muscle-invasive bladder cancer.Journal of nanobiotechnology, 18(1), 1-13.