王伟奇

师资介绍

王伟奇，女，汉族，1990年11月生，博士，副教授，硕士研究生导师。

教育经历：

2012.09-2017.07，中国科学院长春应用化学研究所，高分子化学与物理，博士

2008.09-2012.07，哈尔滨理工大学，化学工程与工艺，学士

工作经历：

2019.07至今，南通大学，药学院，副教授、研究生导师

2017.07-2019.06，南通大学，药学院，讲师

研究方向：

纳米药物

基金项目：

1. 国家自然科学基金青年项目，基于纳米CpG-MOFs的化学动力疗法与巨噬细胞调控研究，2020.01-2022.12，24.00万元，结题，主持；

2. 南通市科技计划项目，黄芪四君子汤联合辐射光动力治疗原位肝癌及其作用机制的研究，2018.07-2020.07，3.00万元，结题，主持；

3. 江苏省高等学校自然科学研究面上项目，阻断免疫检查点增强光动力抗肿瘤免疫逃逸的研究，2018.09-2020.08，3.00万元，结题，主持；

4. 校企合作横向科研攻关课题，22ZH044，金属-有机框架材料复合基底应用于功能性表面增强拉曼散射，2022/01-2023/06，15万元，结题，主持

科研成果：

主要从事智能纳米载药系统研究：构建了系列快速光响应纳米载药系统，提高药物转运效率，显著改善肿瘤治疗效果；发展了智能免疫助剂纳米递药系统，利用肿瘤自身“提供”抗原，从而激持久的抗肿瘤免疫；开发了配位驱动的“维生素纳米复合物”，材料合成简便、成本低、生物相容性高，具有良好成药前景，申请发明专利已获授权。主持国家自然科学基金青年项目，获江苏省科协青年科技人才托举工程资助（JSTJ-2023-006），在Adv Mater, Adv Funct Mater等期刊发表多篇研究性论文。其中中科院JCR分区1区论文6篇，论文累积被引2000余次。

代表性论文：

1. Mengjiao Zhou, Minjian Yuan, Yilan Jin, Qianqian Zhou, Yuting Yu, Jianan Li, Xing Dai, Xiaohua Zheng, Haijun Yu*,Weiqi Wang*, Vitamin B2-based ferroptosis promoter for sono-enhanced nanocatalytic therapy of triple-negative breast cancer.Advanced Functional Materials 2023, 2303899.

2. Weiqi Wang, Qiwen Zhu, Yilan Jin, Jing Gao, Jianan Li, Xiaohua Zheng,Weidong Gao, Madiha Saeed,*Weizhong Sheng,* and Haijun Yu* Self-immolated nanoadjuvant for in situ vaccination immunotherapy of colorectal cancer.Advanced Healthcare Materials 2023,12, 2300524.

3. Yanting Shi, Yutao Zou, M. Shahnawaz Khan, Mengge Zhang, Jiang Yan, Xiaohua Zheng,*Weiqi Wang,*Zhigang Xie,* Metal-organic framework-derived photoelectrochemical sensors: structural design and biosensing technology.Journal of Materials Chemistry C 2023, 11, 3692

4. Weiqi Wang, Yuting Yu, Yilan Jin, Xiao Liu, Min Shang, Xiaohua Zheng*, Tingting Liu* and Zhigang Xie* Two-dimensional metal-organic frameworks: from synthesis to bioapplications.Journal of Nanobiotechnology 2022, 20, 207.

5. DingYi Fu, Xiao Liu, Xiaohua Zheng, Mengjiao Zhou,Weiqi Wang,*Gaoxing Su, Tianqing Liu, Lei Wang, Zhigang Xie,* Polymer-metal-organic framework hybrids for bioimaging and cancer therapy,Coordination Chemistry Reviews 2022, 456, 214393.

6. Weiqi Wang, Yilan Jin, Xiao Liu, Fangmin Chen, Xiaohua Zheng, Tianqing Liu, Yumin Yang*, Haijun Yu,* Endogenous Stimuli-activatable nanomedicine for immune theranostic of cancer,Advanced Functional Materials 2021, 31, 2100386.

7. Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu,Weiqi Wang,* Haijun Yu,* Photoactivatable nanogenerators of reactive species for cancer therapy,Bioactive Materials 2021, 6, 4301.

8. Mengjiao Zhou, Xiao Liu, Fangmin Chen, Lili Yang, Minjian Yuan, Ding-Yi Fu,Weiqi Wang*, Haijun Yu*, Stimuli-activatable nanomaterials for phototherapy of cancer.Biomedical Materials 2021, 16, 042008.

9. Jiaxin Wang, Mengxue Zhou, Fangmin Chen, Xiao Liu, Jin Gao, Weiqi Wang∗, Hui Wang∗, Haijun Yu,∗ Stimuli-sheddable nanomedicine overcoming pathophysiological barriers for potentiating immunotherapy of cancer.Journal of Biomedical Nanotechnology, 2021, 17, 1486.

10. Xiao Liu, Yilan Jin, Tingting Liu, Shengju Yang, Mengjiao Zhou,Weiqi Wang,* Haiju Yu,* Iron-based theranostic nanoplatform for improving chemodynamic therapy of cancer.ACS Biomaterials Science & Engineering 2020, 6, 4834.

11. Weiqi Wang, Yilan Jin, Zhiai Xu, Xiao Liu, Sadia Z. Bajwa, Waheed S. Khan, Haijun Yu,* Stimuli-activatable nanomedicines for chemodynamic therapy of cancer.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2020, e1614.

12. Zhihao Zhao,#Weiqi Wang,# Chenxi Li, Yiqiu Zhang, Tianrong Yu, Renfei Wu, Jiayue Zhao, Zhuang Liu, Jian Liu,* Haijun Yu,* Reactive oxygen species-activatable liposomes regulating hypoxic tumor microenvironment for synergistic photo/chemodynamic therapies.Advanced Functional Materials 2019, 1905013.

13. Weiqi Wang, Madiha Saeed, Yao Zhou, Lili Yang, Dangge Wang, Haijun Yu,* Non-viral gene delivery for cancer immunotherapy.Journal of Gene Medicine2019, 21, e3092.