孙丹
师资介绍
孙丹，女，汉族，1993年12月生，博士，讲师。入选2022年江苏省“双创博士”。
教育经历：
2011.09-2015.06山西大同大学，化学，学士
2015.09-2018.06吉林大学，物理化学，硕士
2018.09-2021.06吉林大学，物理化学，博士
工作经历：
2021.09-至今 南通大学，药学院，讲师
研究方向：
生物纳米传感、微流控液滴分析、表面增强拉曼光谱的生物医学应用
基金项目：
江苏省自然科学基金青年基金，表面增强拉曼光谱技术探究tRNA异戊烯基转移酶提高ML210药效的调控机制，2024/07-2027/06，20万元，在研，主持
江苏省高等学校自然科学基金面上项目， 一体化微流控-SERS光谱平台的构建及用于肝癌诊断的研究，2024/07-2026/07，3万元，在研，主持
江苏省大学生创新创业训练计划，省级立项，202410304160Y，基于水凝胶杂交等离子体纳米结构的SERS传感平台的构建及其生物应用研究，2024.05-2025.04，指导
南通市自然科学基金面上项目，JC2023102，壳聚糖基灌肠剂用于优化结直肠癌的术前放疗及其机制研究，2023/09-2026/08，8万元，在研，参加
企业委托技术开发项目，23ZH222，新型抗衰老膳食补充剂的制剂和质量标准研究，2023/06-2024/03，20万元，已结题，参加
企业委托技术开发项目，23ZH344，OG-018外用纳米制剂的开发和体内外评价，2023/09-2024/09，33万元，已结题，参加
科研成果：
主要工作涉及表面增强拉曼光谱的生物医学应用、微流控液滴分析、生物纳米传感、纳米材料的生物应用等。近年来，在等离子体纳米结构的设计、新型水凝胶柔性SERS基底的构筑、SERS-微流控液滴平台的建立、SERS传感用于生物医学领域中的疾病诊断研究等方面取得了一系列创新性成果。相关研究成果在Analytical Chemistry，Lab on a chip，Sensors and Actuators: B. Chemical，ACS Sensors，iScience等期刊上发表，共发表SCI学术论文19篇。其中中科院JCR分区1区论文9篇，2区论文10篇。相关工作发表后得到国内外同行的广泛关注和认可，被Chemical Reviews，Chemical Society Reviews，Analytical Chemistry等多篇高影响力论文大量引用和评述。授权中国发明专利3项。
授权专利：
1、 一种可再生的用于痕量银离子检测的葡萄糖氧化酶SERS传感芯片及其制备方法 （ZL 2017 1 0248459.7）
2、一种水凝胶负载金纳米粒子SERS基底的制备方法及应用（ZL 2022 1 1565157.X）
3、一种水凝胶柔性SERS基底的制备方法及应用（ZL 2022 1 1565178.1）
代表性论文：
1) Huihui Jin, Tianqing Liu andDan Sun*, Target induced hot spot construction for sensitive and selective surface enhanced Raman scattering detection of matrix metalloproteinase MMP 9.Microchimica Acta, 2024,191, 105.
2) Yueyuan Zhuang, Han Dong, Tianqing Liu, Yongmei Zhao, Yan Xu, Xiaojuan Zhao* andDan Sun*, Highly sensitive and selective SERS detection of caspase-3 during cell apoptosis based on the target-induced hotspot effect.Analyst, 2024,149, 490−496.
3）Dan Sun*, Guohua Qi, Xuan Yi, Hongyan Zhu, and Yongdong Jin*, Smart ratiometric SERS nanoprobe for real-time monitoring hydrogen peroxide in living cells during NADH treatment associated with ferroptosis.Analytical Chemistry,2023,95, 18075−18081.
4) Guohua Qi, Yuanzhe Wang, Tianqing Liu*,Dan Sun*, “On-site” analysis of pesticide residues in complex sample matrix by plasmonic SERS nanostructure hybridized hydrogel.Analytica Chimica Acta, 2023,1282, 341903.
5) Lixing Xu, Xing Du, Tianqing Liu,Dan Sun*, In situ and dynamic SERS monitoring of glutathione levels during cellular ferroptosis metabolism.Analytical and Bioanalytical Chemistry, 2023,415, 6145–6153.
6）Dan Sun*, Fanghao Cao, Xuan Yi, Hongyan Zhu, Guohua Qi, Weiqing Xu and Shuping Xu*, MicroRNA-21 expression in single living cells revealed by fluorescence and SERS dual-response microfluidic droplet platform.Lab on a Chip, 2022,22, 2165–2172.
7) Fanghao Cao, Minmin Wang, Xuan Yi andDan Sun*, Enzyme-triggered click chemistry combined with surface-enhanced Raman spectroscopy for the simple and sensitive detection of alkaline phosphatase activity from complex biological samples.Analyst, 2022,147, 2494–2499.
8) Guohua Qi, Xing Du, Xuan Yi, Minmin Wang, Hongyan Zhu* andDan Sun*, A SERS and fluorescence dual-channel microfluidic droplet platform for exploring telomerase activity at the single-cell level.Analyst, 2022,147, 5062–5067.
9)Dan Sun, Fanghao Cao, Huimin Wang, Shulin Guan, Ailing Su, Weiqing Xu and Shuping Xu*, SERS hydrogel pellets for highly repeatable and reliable detections of significant small biomolecules in complex samples without pretreatment.Sens. Actuators, B, 2021,327, 128943.
10)Dan Sun, Weiqing Xu, Chongyang Liang*, Wei Shi and Shuping Xu*, Smart surface-enhanced resonance Raman scattering nanoprobe for monitoring cellular alkaline phosphatase activity during osteogenic differentiation.ACS Sensors, 2020,5, 1758−1767.
11)Dan Sun, Guohua Qi, Kongshuo Ma, Xiaozhang Qu, Weiqing Xu, Shuping Xu* and Yongdong Jin*, Tumor microenvironment-activated degradable multifunctional nanoreactor for synergistic cancer therapy and glucose SERS feedback.iScience, 2020,23, 101274.
12）Guohua Qi#,Dan Sun#, Yu Tian, Chen Xu, Ying Zhang, Dandan Wang, Kongshuo Ma, Shuping Xu,* Yongdong Jin*, Fast activation and tracing of caspase 3 involved cell apoptosis by combined electrostimulation and smart signal-amplified SERS nanoprobes,Analytical Chemistry,2020,92, 7861−7868.
13)Dan Sun, Fanghao Cao, Yu Tian, Aisen Li, Weiqing Xu, Qidan Chen, Wei Shi and Shuping Xu*, Label-free detection of multiplexed metabolites at single-cell level via a SERS-microfluidic droplet platform.Analytical Chemistry,2019,91, 15484−15490.
14)Dan Sun, Fanghao Cao, Weiqing Xu, Qidan Chen, Wei Shi and Shuping Xu*, Ultrasensitive and simultaneous detection of two cytokines secreted by single cell in microfluidic droplets via magnetic-field amplified SERS.Analytical Chemistry,2019, 91, 2551−2558.
15)Dan Sun, Fanghao Cao, Lili Cong, Weiqing Xu, Qidan Chen, Wei Shi and Shuping Xu*, Cellular heterogeneity identified by single-cell alkaline phosphatase (ALP) via a SERRS microfluidic droplet platform.Lab on a Chip, 2019,19, 335–342.
16)Dan Sun, Weiqing Xu and Shuping Xu*, Ultrasensitive Raman sensing of alkaline phosphatase activity in serum based on an enzyme catalyzed reaction.Anal. Methods, 2019,11, 3501–3505.
17)Dan Sun, Xiangyuan Liu, Shuping Xu, Yu Tian, Weiqing Xu and Yanchun Tao*, Quantitative determination of urine glucose: combination of laminar flow in microfluidic chip with SERS probe technique.Chem. Res. Chin. Univ., 2018, 34(6), 899–904.
18)Dan Sun, Guohua Qi, Fanghao Cao, Weiqing Xu, Qidan Chen and Shuping Xu*, A recyclable silver ions-specific surface-enhanced Raman scattering (SERS) sensor. Talanta, 2017,171, 159–165.
19)Dan Sun, Guohua Qi, Shuping Xu* and Weiqing Xu, Construction of highly sensitive surface-enhanced Raman scattering (SERS) nanosensor aimed for the testing of glucose in urine.RSC Adv., 2016,6, 53800–53803.