丁姝姝

师资介绍

丁姝姝，女，汉族，1991年08月生，博士，副教授，硕士生导师。

教育经历：

2009.09-2013.06天津师范大学，化学，学士

2013.09-2018.06华东师范大学，分析化学，博士

工作经历：

2018.07-2021.06南通大学，药学院，讲师

2021.07-至今   南通大学，药学院，副教授

研究方向：

疾病标志物及药物分析

社会学术兼职：无

基金项目：

1. 国家自然科学基金青年项目，22104065，“开-关”型自驱动传感平台的构建及其脑化学活体研究，2022/01-2024/12，30万元，在研，主持

2. 中国博士后科学基金面上项目，2023M731817，基于微型自驱动传感平台用于神经退行性疾病的诊疗研究，2023/09-2026/08，8万元，在研，主持

3. 江苏省高校自然科学研究项目，21KJB150024，无机纳米孔阵列的构建及其在蛋白质单分子分析中的应用，2021/08-2023/08，3万元，已结题，主持

4. 江苏省自然科学基金青年项目，BK20200972，基于HPV E6/E7适配体的诊疗一体化纳米探针的构建及作用机制研究，2020/07-2023/06，20万元，已结题，参加

科研成果：

课题组致力于将分析技术与神经科学相结合，发展神经退行性疾病标志物检测新技术，探究神经病理分子新机制。近年来，围绕与脑功能疾病相关的重要神经活性分子(糖类、活性氧、淀粉样多肽)，设计并合成了多种刺激响应性高分子材料，通过构建无机-有机复合体系，建立了多种电化学分析新方法并取得了系列研究成果。截至目前，以第一作者在Analytical Chemistry, ACS Sensors等期刊上共发表SCI论文12篇，其中中科院JCR一区6篇，二区4篇。

成果奖励：无

代表性论文：

1. DingS,LiuC,ZhuY,LiJ,ShiG,ZhuA*,Rare Earth-Carbon Dots Nanocomposite-Modified Glass Nanopipettes: Electro-Optical Detection of Bacterial ppGpp,Anal. Chem., 2024,96,4521-4527.

2. WangJ, ChenW,CaoL,ZhouM,GengY,LiuY,DingS*,FuD*, Glutathione S-transferase Templated Copper Nanoclusters as a Fluorescent Probe for Turn-On Sensing of Chlorotetracycline,Nanoscale Adv., 2024, 6,722-731.

3. Ding S, Zhu Y, Zhu A, Shi G*,AStimuli-ResponsivePolymerModifiedNanopore forNeasuring β-amyloidPeptide andZincIons inBrains ofLiveMice with Alzheimer'sDisease,Sens. Diagn., 2023,2, 851-857.

4. DingS,ShiG,ZhuA*,Stimuli-ResponsivePolymers forInterfaceEngineering towardEnhancedElectrochemicalAnalysis ofNeurochemicals,Chem.Commun., 2022, 58, 1317-1387.

5. YangF,ZhuY,ZhangC, YangZ,YuanJ,ZhuQ*,DingS*,A Highly Sensitive and Selective Artificial Nanochannel for In Situ Detection of Hydroxyl Radicals in Single Living Cell,Anal.Chim.Acta, 2022, 1235, 340537.

6. CaoL, ZhouM, WangJ, ZhuQ, LiuTi,DingS*, FuD*, Gold/Silver Bimetallic Nanoclusters Protected by Glutathione S Transferase for Colorimetric Sensing of Oxytetracycline,ACS Appl. Nano Mater., 2022, 5, 11176-11184.

7. DingS, LiuC, FuD, ShiG,ZhuA*,Coordination of Ligand-Protected Metal Nanoclusters and Glass Nanopipettes: Conversion of Liquid-Phase Fluorometric Assay into Enhanced Nanopore Analysis,Anal. Chem., 2021,93,1779-1785.

8. DingS,LiM,GongH,ZhuQ, ShiG, ZhuA*,Sensitive andSelectiveMeasurement ofHydroxylRadicals atSubcellularLevel withTungstenNanoelectrodes,Anal. Chem., 2020, 92, 2543-2549.

9. DingS^#, XuY^#, LiuQ, GuH,Shi G*, ZhuA*,InterfaceEngineering ofMicroelectrodes towardUltrasensitiveMonitoring of β-amyloidPeptides inCerebrospinalFluid in Alzheimer’sDisease,Analyst, 2020, 145, 2331-2338.

10. DingS, LiuY, MaC, ZhangJ, ZhuA*, ShiG*, Development of Glass-Sealed Gold Nanoelectrodes for In Vivo Detection of Dopamine in Rat Brain,Electroanalysis, 2018, 30, 1041-1046.

11. DingS,CaoS,Liu Y,LianY,ZhuA*,ShiG*;RationalDesign ofAStimuli-ResponsivePolymerElectrodeInterfaceCoupled withInVivoMicrodialysis forMeasurement ofSialicAcid inLiveMouseBrain in Alzheirmer'sDisease,ACS Sens., 2017, 2,394-400. 

12. DingS,CaoS,ZhuA*, ShiG*,WettabilitySwitching ofElectrode forSignalAmplification: Conversion ofConformationalChange ofStimuli-ResponsivePolymer intoEnhancedElectrochemicalChiralAnalysis,Anal. Chem., 2016, 88,12219-12226.