范博义

师资介绍

范博义，男，汉族，1989年01月生，博士，副教授，硕士生导师。入选江苏高校“青蓝工程”优秀青年骨干教师和江苏省“科技副总”。

教育经历：

2005.09-2009.06华南理工大学，制药工程，学士

2010.09-2015.06中国药科大学，中药学，博士

工作经历：

2015.11-2020.07南通大学，药学院，讲师

2019.11-2020.11美国Scripps研究所，化学系，访问学者

2020.07-至今 南通大学，药学院，副教授

研究方向：

天然药物化学，中药学

社会学术兼职：

中华中医药学会中药化学分会青年委员

基金项目：

1. 江苏省高校“青蓝工程”优秀青年骨干教师培养对象，2024/07-2027/07，4万，在研，主持

2. 国家自然科学基金面上项目，32370419，树脂糖苷类Sec61α抑制剂的发现及其潜在抗冠状病毒活性研究，2024/01-2027/12，50万，在研，主持

3. 江苏省产学研合作项目，BY20230349，基于功效及香气特征的烟用天然中草药提取物的研究与开发，2023/06-2024/06，30万，在研，主持

4. 南通市科技项目，JC2021094，香樟叶中天然活性化合物的发现及其药理机制研究，2021/07-2023/06，3万，已结题，主持

5. 国家自然科学基金青年项目，31800281，基于自噬-溶酶体通路的土丁桂中潜在抗阿尔茨海默症树脂糖苷类成分的发现及其作用机制研究，2019/01-2021/12，26万，已结题，主持，已结题

6. 南通市科技项目，MS12016038，土丁桂中新颖抗AD活性成分及作用机制研究，2016.10-2018.09，3万，已结题，主持

科研成果：

长期从事中药学及天然药物化学的科研工作，主要聚焦于天然寡糖脂类活性成分的开发和利用，已构建成熟的高效研究策略。迄今已对菟丝子、土丁桂、毛牵牛等多种传统中草药进行研究，发现一系列结构新颖、活性良好的天然寡糖脂类成分，为药物开发提供新颖的先导化合物。

研究工作受到国家自然科学基金委员会、江苏省科技厅和南通市科技局各类基金项目支持，以项目负责人主持国家自然基金面上项目及青年项目各1项，江苏省产学研项目1项，南通市科研项目2项。以第一作者或通讯作者在Medicinal Research Reviews, Organic Letters, Journal of Natural Products等国内外专业期刊发表学术论文20余篇。研究成果为中药质量评价、临床应用推广和创新药物研发等提供重要支撑，为推进我国中药现代化的发展做出积极贡献。

代表性论文：

1. Yan-Ni Wu, You-Jia Lu, Ying Yi, An-Dong Wang, Wen-Li Wang, Min Yang,Bo-Yi Fan*, Guang-Tong Chen* Biotransformation of asiatic acid byCunninghamella echinulata andCircinella muscae to discover anti-neuroinflammatory derivatives.Natural Product Research, 2023, 37(16), 2712-2717.

2. Xing Jiang^#, Xi-Han Zhang^#, Yu-Xin Li, Kai Chen, Bin Lin, Tian-Qi Lu, Min Yang, Guang-Tong Chen,Bo-Yi Fan*, Wen-Li Wang*. Chemical constituents from the leaves ofCinnamomum camphora and theirα-glucosidase inhibitory activities.Phytochemistry Letters 2023, 57, 101–105.

3.Bo-Yi Fan^#*, Xing Jiang^#, Yu-Xin Li, Wen-Li Wang, Min Yang, Jian-Lin Li, An-Dong Wang, Guang-Tong Chen*. Chemistry and biological activity of resin glycosides from Convolvulaceae species.Medicinal Research Reviews 2022, 42(6), 2025-2066.

4. Wen-Li Wang^#, Yu-Xin Li^#, Ye He^#, Xing Jiang, Ying Yi, Xi-Han Zhang, Shi-Yu Zhang, Guang-Tong Chen, Min Yang, Jia-Lie Luo,Bo-Yi Fan*. Progress in the total synthesis of resin glycosides.Frontiers in Chemistry 2022, 10, 1036954.

5. You-Jia Lu^#, Yi-Fei Tang^#, Yan-Ni Wu, Xue-Ying Zhang, Ying Yi, Wen-Li Wang*, An-Dong Wang, Min Yang,Bo-Yi Fan*, Guang-Tong Chen*. Microbial transformation of betulonic acid byCircinella muscae CGMCC 3.2695 and anti-neuroinflammatory activity of the products.Phytochemistry 2022, 204, 113431.

6.Cheng-Jiao Chu^#, Kai-Nan Song^#, Yong-Zhen Zhang, Min Yang,Bo-Yi Fan*, Hui-Lian Huang and Guang-Tong Chen*. Biotransformation of ursolic acid byCircinella muscae and their anti-neuroinflammatory activities of metabolites.Natural Product Research 2022, 36(11), 2777-2782.

7. Kai-Nan Song^#, You-Jia Lu^#, Cheng-Jiao Chu, Yan-Ni Wu, Hui-Lian Huang,Bo-Yi Fan*, and Guang-Tong Chen*. Biotransformation of betulonic acid by the fungusRhizopus arrhizus CGMCC 3.868 and antineuroinflammatory activity of the biotransformation products.Journal of Natural Products 2021, 84(10), 2664–2674.

8. Jin-Yuan Xu^#, Ye He^#, Ai-Wen Zhang, Yun Lu, Guang-Tong Chen, Min Yang,Bo-Yi Fan*. Isolation of evolvulic acids B and C, two new components of crude resin glycoside fraction fromEvolvulus alsinoides.Natural Product Research2021,35(21), 3766-3771.

9. Yun Lu^#, Ye He^#, Min Yang,Bo-Yi Fan*. Arvensic acids K and L, components of resin glycoside fraction fromConvolvulus arvensis.Natural Product Research2021, 35(14), 2303-2307.

10.Bo-Yi Fan*, Yun Lu, Jin-Yuan Xu, Ai-Wen Zhang, Min Yang, Guang-Tong Chen. Evolvulin III, a new resin glycoside isolated fromEvolvulus alsinoides.Phytochemistry Letters 2020, 39, 132–134.

11.Bo-Yi Fan, Yun Lu, Min Yang, Jian-Lin Li*, Guang-Tong Chen*. Evolvulins I and II, resin glycosides with a trihydroxy aglycone unit fromEvolvulus alsinoides.Organic Letters 2019, 21, 6548–6551.

12.Bo-Yi Fan, Ye He, Yun Lu, Min Yang, Qing Zhu, Guang-Tong Chen*, Jian-Lin Li*. Glycosidic acids with unusual aglycone units fromConvolvulus arvensis. Journal of Natural Products2019, 82, 1593-1598.

13.Bo-Yi Fan, Bao-Cheng Jiang, Sen-Sen Yan, Bo-Hui Xu, Hui-Lian Huang, Guang-Tong Chen* Anti-inflammatory 18β-glycyrrhetinin acid derivatives produced by biocatalysis. Planta Medica2019, 85, 56-61.

14. Jian-Lin Li, Xin Jiang, Xin-Pei Liu, Cai-Wei He, Yu-Xin Di, Sai-Jian Lu, Hui-Lian Huang, Bin Lin, Dong Wang*,Bo-Yi Fan*. Antibacterial anthraquinone dimers from marine derived fungusAspergillussp.Fitoterapia2019, 133, 1-4.

15. Guang-Tong Chen, Yun Lu, Min Yang, Jian-Lin Li*,Bo-Yi Fan*. Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: a systematic review.Phytotherapy Research 2018, 32(5), 823-864.

16.Bo-Yi Fan^#, Yun Lu^#, Hong Yin, Ye He, Jian-Lin Li*, Guang-Tong Chen*. Arvensic acids A-D, novel heptasaccharide glycosidic acids as the alkaline hydrolysis products of crude resin glycosides fromConvolvulus arvensis.Fitoterapia2018, 131, 209-214.

17.Bo-Yi Fan, Zhong-Rui Li, Ting Ma, Yu-Cheng Gu, Hui-Jun Zhao,Jian-Guang Luo*, Ling-Yi Kong*. Further screening of the resin glycosides in the edible water spinach and characterisation on their mechanism of anticancer potential.Journal of Functional Foods2015, 19, 141-154.

18.Bo-Yi Fan, Yu-Cheng Gu, Ye He, Zhong-Rui Li, Jian-Guang Luo,* Ling-Yi Kong*. Cytotoxic resin glycosides fromIpomoea aquatica and their effects on intracellular Ca²⁺ concentrations.Journal of Natural Products2014, 77, 2264−2272.

19.Bo-Yi Fan, Jian-Guang Luo, Yu-Cheng Gu, Ling-Yi Kong*. Unusual ether-type resin glycoside dimers from the seeds ofCuscuta chinensis.Tetrahedron 2014, 70, 2003-2014.