刘名轩

师资介绍

刘名轩，男，汉族，1991年1月生，博士，副教授，硕士生导师。入选澳门青年学者。

教育经历：

2014.09-2017.06中科院大连化物所，扬州大学联合培养，化学，硕士，导师：李灿院士，俞磊教授

2017.09-2020.06北京师范大学，化学生物学，博士，导师：卢忠林教授

2024.01-2025.12澳门科技大学，中西医结合，博士后（澳门青年学者）导师：吴其标教授

工作经历：

2020.07-2020.12浙江中医药大学，药学院，讲师

2021.01-至今 南通大学，药学院，副教授

研究方向：

核酸药物递送，碳基递送载体研发

社会学术兼职：

中国药理学会补益药药理专业委员会委员、中国化学会会员。ACS Nano，Advanced Science, Cell proliferation, Food Science and Human Wellness等著名期刊审稿人。

主持基金项目：

1. 国家自然科学基金，82200739，主持（2023/01-2025/12，30万，在研）

2. 澳门青年学者项目，AM2023030，主持，（2024/01-2025/12，72万，在研）

3. 南通市青年项目，JC12022025,主持（2023/01-2024/06，3万，结题）

4. 南通大学高层次人才项目，135421623022，主持（4万，结题）

5. 江苏省大学生创新创业计划项目，202310304156Y，指导教师（2023.05-2024.04，6000元，结题）

科研成果：

近5年侧重于核酸与药物递送以及功能纳米平台在肝纤维化与帕金森疾病治疗中应用的研究。课题组主要应用化学生物学、生物材料学、组织与细胞形态学、药物化学与药理学、基因干预与行为学等多学科交叉策略研究并构建碳基功能平台，并深入研究其在帕金森和肝纤维化治疗中的作用。

研究工作受到国家自然科学基金委员会、全国博士后管委会、澳门科学技术协进会和南通市科技局各类基金项目支持，包括1项国家自然科学基金、1项澳门青年学者项目、1项南通市科技计划项目支持，取得了一系列具有显著科学价值和创新意义的成果，其中有关氮化碳基递送系统在抗肝纤维化与帕金森的研究为新型递送系统的构建与相关疾病的治疗提供了新的思路。

在Chemical Engineering Journal、Advanced Healthcare Materials, ACS Applied Materials & Interfaces，Science China-Chemistry，Chinese Chemical Letters，Phytotherapy Research, Bioengineering & Translational Medicine，Neural Regeneration Research, Journal of Materials Chemistry B等期刊发表专业学术论文十余篇，其中中科院JCR分区1区论文4篇，2区论文6篇，影响因子10分及以上论文5篇。

代表性论文：

1. Xiao-Ling Zhang, Ying-Ying Gu, Yan-Chao Liu, Yu-Ting Cai, Hao Sun, You-Xia Liu,Ming-Xuan Liu* (唯一通讯),  Near-infrared enhanced organic se-doped carbon nitride quantum dots nanozymes as SOD/CAT mimics for anti-Parkinson via ROS-NF-κB-NLRP3 inflammasome axis, Chemical Engineering Journal,2024, 499, 156028.(IF: 13.3)

2. Ming-Xuan Liu,Yan-Chao Liu, Yu-Ting Cai, Ying-Ying Gu, Ya-Qi Zhu, Nan Zhang, Wei-Zhong Zhu, Yong-Hong Liu, Lei Yu,* Qi-Tao Zhang,* Xiao-Ling Zhang*, Self-Produced O2 CNs-Based Nanocarriers of DNA Hydrophobization Strategy Triggers Photodynamic and Mitochondrial-Derived Ferroptosis for Hepatocellular Carcinoma Combined Treatment,Advanced Healthcare Materials,2024, 2402110. (IF: 10.0)

3. Ming-Xuan Liu, *^#Yu-Ting Cai, ^# Ruo-Jia Wang, Peng-Fei Zhu, Yan-Chao Liu, Hao Sun, Yong Ling, Wei-Zhong Zhu, Jing Chen*, Xiao-Ling Zhang*,Aggregation-Induced Emission CNs-Based Nanoparticles for Againsting Hypoxic Liver Fibrosis via Triggering HSCs Ferroptosis and Enhancing Photodynamic Therapy,ACS Applied Materials & Interfaces,2024, 16, 33021−33037. (IF: 8.3)

4. Ming-Xuan Liu, * Li Xu, Yu-Ting Cai, Ruo-Jia Wang, Ying-Ying Gu, Yan-Chao Liu, Yu-Jin Zou, Yong-Mei Zhao, Jing Chen,* Xiao-Ling Zhang*, Carbon Nitride‐Based Sirna Vectors with Self‐Produced O₂ Effects for Targeting Combination Therapy of Liver Fibrosis via HIF‐1α‐mediated TGF‐β1/Smad Pathway.Advanced Healthcare Materials,2023, 12, 2301485.(IF: 10.0)

5. Yingying Gu, Jiaying Zhang, Xinru Zhao, Wenyuan Nie, Xiaole Xu,Mingxuan Liu*,Xiaoling Zhang*, Olfactory dysfunction and its related molecular mechanisms in Parkinson’s disease.Neural Regeneration Research,2024,19,583-590. (IF: 5.9)

6. Ming-Xuan Liu*, LiXu, Jia-Yi Jiang, Hai-Chen Dong, Peng-Fei Zhu, Lei Cao, Jing Chen*, Xiao-Ling Zhang*, Light controlled self-escape capability of non-cationic carbon nitride-based nanosheets in lysosomes for hepatocellular carcinoma targeting stimulus-responsive gene delivery.Bioengineering & Translational Medicine,2023, 8(5), e10558.(IF: 7.4)

7. Ming-Xuan Liu, Li Xu, Peng-Fei Zhu, Xin Li, Miao Shan, Wei Jin, Jing Chen*, Yong Ling*, Xiao-Ling Zhang*,Two-photon excited red-green "discoloration" bioprobes for monitoring lipid droplets and lipid droplet-lysosomal autophagy,Journal of Materials Chemistry B,2023, 11, 3186-3194. (IF: 7.0)

8. Xiaoling Zhang^*，Xiaoyan Zhang，Xiaoqun Ge，Mingxuan Liu^*, Mangiferin prevents hepatocyte epithelial‐mesenchymal transition in liver fibrosisvia targeting HSP27-mediated JAK2/STAT3 and TGF-β1/Smad pathway.Phytotherapy Research,2022,36(11), 4167-4182. (IF: 7.2)

9. Ming-Xuan Liu*, Xiao-Ling Zhang, Jing-Bo Yang, Zhong-Lin Lu*, Qi-Tao Zhang*, Highly water-dispersible PCN nanosheets as light-controlled lysosome self-promoting escape type non-cationic gene carriers for tumor therapy. Journal of Materials Chemistry B,2022, 10, 5430. (IF: 7.0)

10. Ming-Xuan Liu*,Jia-Ying Zhang, Xiao-Ling Zhang*, Application of graphite carbon nitride in the field of biomedicine: Latest progress and challenges,Materials Chemistry and Physics,2022, 281, 125925. (IF: 4.6)

11. Mingxuan Liu, Xiaoling Zhang, Sainan Chu, Yanyu Ge, Tao Huang, Yonghong Liu∗, Lei Yu∗, Selenization of cotton products with NaHSe endowing the antibacterial activities,Chinese Chemical Letters,2022, 33, 205-208. (IF: 9.1)

12. Ming-Xuan Liu, Xu-Ying Liu, Jin-Yu Liu, Jin-Tao Tang, Ke Shi, Jie Mao, Zhong-Lin Lu,* Hai-Jun Qiao,* Lan He*, Di[12]aneN₃Functionalized Green Fluorescent Protein Chromophore for GFP Luminescence Simulation and Efficient Gene Transfection In Vitro andIn Vivo, ACS Applied Bio Materials,2021, 4, 7111–7122. (IF: 4.7)

13. Ming-Xuan Liu, Le-Le Ma, Xu-Ying Liu, Jin-Yu Liu, Zhong-Lin Lu*, Rui Liu*, Lan He*, Combination of [12]aneN₃ and Triphenylamine-Benzylideneimidazolone as Nonviral Gene Vectors with Two-Photon and AIE Properties,ACS Applied Materials & Interfaces,2019,11, 42975-42987. (IF: 10.383)

14. Mingxuan Liu, Yiming Li, Lei Yu*, Qing Xu, Xuefeng Jiang*, Visible light-promoted, iodine-catalyzed selenoalkoxylation of olefins with diselenides and alcohols in the presence of hydrogen peroxide/air oxidant: an efficient access to α-alkoxyl selenides.Science China-Chemistry,2018,61, 294–299. (IF: 10.138)

授权专利

1.刘名轩，丁莹，朱鹏飞，张小玲；一种新型脂滴、溶酶体双靶向可变色荧光探针的制备及其应用，专利授权号：ZL 202211344452.2

2.刘名轩，张小玲，朱鹏飞，顾莹莹；近红外激发HSCs靶向、脂酶响应的氮化碳基纳米片制备方法及其应用，发明人：专利授权号：ZL 202211595050.X