朱卫忠
师资介绍
朱卫忠，男，汉族，1964年11月生，博士，教授，博士生导师。入选江苏省特聘教授。
教育经历：
1982.09-1986.06 南通医学院，临床医学，学士
1986.09-1989.06 苏州医学院，药理学，硕士
1995.09-1998.06 北京医科大学大学，病理生理学，博士
工作经历：
1989.07-1999.01 南通医学院，药理学，助理教授、讲师、副教授
2006.03-2013.06 南通大学 特聘教授
1999.01-2003.10美国国立卫生研究院（NIH），博士后
2003.11-2011.10美国国立卫生研究院（NIH）， 研究员（staff scientist）
2011.11-2014.12 美国天普大学医学院,助理教授
2015.01-至今 南通大学 特聘教授
研究方向：
心血管药理学， 病理生理学
社会学术兼职:
现任中国生理学会理事，中国药理学会表观遗传药理专业委员会常务委员，中国病理生理学会受体专业委员会委员，心血管专业委员会委员，心血管转化医学专业委员会委员。南通市小分子研发重点实验室主任。
研究方向：
心血管药理学， 病理生理学
基金项目：
1. 国家自然科学基金面上项目， 81300345， 精氨酸加压素受体V1A在心脏中作用， 2014.01-2017.12，70 万，主持，结题
2. 国家自然科学基金面上项目，81541008 Bcl2 相关基因3(BAG3)在缺血性心肌病中作用，2016.01-2016.12，10 万，主持，结题
3. 国家自然科学基金面上项目， 81770400，GRK2在血管加压素诱导心衰中作用， 2018.01-2021.12，65万，主持，结题
4. 江苏省特聘教授人才计划项目，2013年度，GPCR在心血管生理和病理调节中作用， 2013.11-2.116.10，100万，主持，结题
科研成果：
近年来系统地研究Ｇ蛋白偶联受体在心血管中作用。首次发现β2-AR与功能相反的Gs和Gi蛋白偶联，介导心肌细胞的命运；发现β1-AR细胞凋亡信号由钙依赖性蛋白激酶II介导；发现G蛋白偶联激酶在β2-AR的Gi蛋白偶联在心脏病理生理中作用；首次发现脉管加压素受体参与肾上腺素受体调节心脏功能。以第一作者或通讯作者在J Clin Invest、Proc Natl Acad Sci、Circ Res、 J Biol Chem等发表研究论文30多篇。SCI论文100余篇，被SCI文章引用4000多次。
1. Hongyan Qian , Yi Qian, Yi Liu , Jiaxin Cao , Yuhang Wang , Aihua Yang，Wenjing Zhao, Yingnan Lu, Huanxin Liu, Weizhong Zhu. Identification of Novel Biomarkers Involved in doxorubicin-induced Actute and chronic cardiotocxicity respectively by integrated bioinformatics Frontiers in Cardiovascular Medicine,2023 Jan 11:9:996809. doi: 10.3389/fcvm.2022.996809
2. Na Yao, Beibei Guo,YuhangWang, Ying Hu, Xiaofang Zhu, Jiaxin Cao, Yi Liu1 Yi Qian, Hua Sang, Weizhong Zhu. β-arrestin2 Mediates the Arginine Vasopressin-Induced Expression of IL-1β in Murine Hearts Front Biosci (Landmark Ed). 2023 Jan 10;28(1):7. doi: 10.31083/j.fbl2801007.
3. Guo B, Cao J, Liu Y, Wang Y, Qian Y, Chen G, Zhu W. Cardiac Protection of a Novel Lupane-Type Triterpenoid from Injuries Induced by Hypoxia-Reperfusion. Int J Mol Sci. 2022 Aug 22;23(16):9473. doi: 10.3390/ijms23169473.
4. Zhao LL, Gu JN, Zhu XF, Hu Y, Cao H, Yao N, Sang H, Guo BB, Wang YH, Qian HY, Zhu WZ. HSC70-JNK-BAG3 complex is critical for cardiomyocyte protection of BAG3 through its PXXP and BAG structural domains. Front Biosci (Landmark Ed). 2021 May 30;26(6):102-113.
5. Cao H, Hu Y, Zhu X, Yao N, Gu J, Wang Y, Zhu W.O-GlcNAc transferase affects the signal transduction of β1 adrenoceptor in adult rat cardiomyocytes by increasing the O-GlcNAcylation of β1 adrenoceptor. Biochem Biophys Res Commun. 2020 Jul 12;528(1):71-77. doi: 10.1016/j.bbrc.2020.05.010.
6. Wu Yu-ting, CHEN Ying, ZHU Xiao-li, ZHU Wei-zhong Study on the occurrence and influencing factors of cardiotoxicity in breast cancer patients treated with epirubicin Chinese Journal of Drug Application and Monitoring, 2020, 17(5) 1672-8157(2020)05-0292-04.
7. Sun SZ, Cao H, Yao N, Zhao LL, Zhu XF, Ni EA, Zhu Q, Zhu WZ. β-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK1/2-NF-κB signal pathway in murine hearts.Acta Pharmacol Sin. 2020 Feb;41(2):198-207. doi: 10.1038/s41401-019-0292-y.
8. Ni E, Zhao L, Yao N, Zhu X, Cao H, Sun S, Zhu W. The PXXP domain is critical for the protective effect of BAG3 in cardiomyocytes. Clin Exp Pharmacol Physiol. 2019 May;46(5):435-443. doi: 10.1111/1440-1681.13031. Epub 2019 Mar 7。
9. Zhang Y, Wang WE, Zhang X, Li Y, Chen B, Liu C, Ai X, Zhang X, Tian Y, Zhang C, Tang M, Szeto C, Hua X, Xie M, Zeng C, Wu Y, Zhou L, Zhu W, Yu D, Houser SR, Chen X. Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart. Circ Res. 2019 Jun 7;124(12):1760-1777. doi: 10.1161/CIRCRESAHA.118.313417. Epub 2019 Apr 15.
10. Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, Hall D, Wu J, Shi Y,Zhu Q, Chen C, Thiel WH, Zhan X, Weiss RM, Zhan F, Musselman CA, Pufall M, Zhu W, Au KF, Hong J, Anderson ME, Grueter CE, Song LS. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018 Dec 21;362(6421):eaan3303. doi: 10.1126/science.aan3303. Epub 2018 Nov 8
11. Xu F, Sun S, Wang X, Ni E, Zhao L, Zhu W. GRK2 Mediates Arginine Vasopressin-Induced Interleukin-6 Production via Nuclear Factor-κB Signaling Neonatal Rat Cardiac Fibroblast. Mol Pharmacol. 2017 Sep;92(3):278-284
12. Lingling Zhang, Yunxuan Chen, Xi Zhao, Xiaojun Wang, Feifei Xu, Yifan Wang, Anthony Yiu-Ho Woo, Weizhong Zhu. Vasopressin receptor V1A mediates cell proliferation through GRK2-ERK1/2 pathway in A7r5 cells. Eur J Pharmacol. 2016 Dec 5;792:15-25. doi: 10.1016/j.ejphar.2016.10.023. Epub 2016 Oct 20.
13. Yunxuan Chen, Xiaojun Wang, Lingling Zhang, Feifei Xu, MD, Yifan Wang, Anthony Yiu-Ho Woo, Weizhong ZhuGRK2/b-arrestin mediates arginine vasopressin-induced cardiac fibroblast proliferation. Clin Exp Pharmacol Physiol. 2017 Feb;44(2):285-293. doi: 10.1111/1440-1681.12696
14. Zhu W, Tsang S, Browe DM, Woo AY, Huang Y, Xu C, Liu JF, Lv F, Zhang Y, Xiao RP. Interaction of b1-adrenoceptor with RAGE mediates cardiomyopathy Via CaMKII signaling. JCI insight, 2016; 1(1): e84969
15. Wang J, Wang Y, Zhang W, Zhao X, Chen X, Xiao W, Zhang L, Chen Y, Zhu W. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1; 21:502-13.
16. Woo AY, Song Y, Zhu W, Xiao RP. Advances in Receptor Conformation Research: The Quest for Functionally Selective Conformations Focusing on the β2 -Adrenoceptor. Br J Pharmacol. 2015 Dec;172(23):5477-88
17. Woo AY, Song Y, Xiao R, Zhu W. Biased β2 -adrenoceptor signalling in heart failure: pathophysiology and drug discovery. Br J Pharmacol. Dec;172(23):5444-56.
18. Chen QQ, Zhang W, Chen XF, Bao YJ, Wang J, Zhu WZ. Electrical field stimulation induces cardiac fibroblast proliferation through the calcineurin-NFAT pathway. Can J Physiol Pharmacol. 2012 Dec;90(12):1611-22
19. Tilley DG, Zhu W, Myers VD, Barr LA, Gao E, Li X, Song J, Carter RL, Makarewich CA, Yu D, Troupes CD, Grisanti LA, Coleman RC, Koch WJ, Houser SR, Cheung JY, Feldman AM. β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling. Circulation. 2014 Nov 11;130(20):1800-11
20. Zhu W, Tilley DG, Myers VD, Tsai EJ, Feldman AM.Increased Vasopressin 1A Receptor Expression in Failing Human Hearts. J Am Coll Cardiol. 2014 Feb 4;63(4):375-6.
21. Zhu W(co-corresponding author), Tilley DG, Myers VD, Coleman RC, Feldman AM. Arginine Vasopressin Enhances Cell Survival Via a GRK2-βarrestin1-ERK1/2-Dependent Pathway in H9c2 Cells. Mol Pharmacol. 2013，84(2):227-35
22. Zhu W (co-corresponding author), Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP. Gi-biased β2AR signaling links GRK2 upregulation to heart failure.Circ Res. 2012; 110(2):265-74.
23. Hamad EA, Zhu W (co-corresponding author), Chan TO, Myers V, Gao E, Li X, Zhang J, Song J, Zhang XQ, Cheung JY, Koch W, Feldman AM. Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload.PLoS One. 2012;7(7):e39919.
24. Chen QQ, Zhang W, Chen XF, Bao YJ, Wang J, Zhu WZ. Electrical field stimulation induces cardiac fibroblast proliferation through the calcineurin-NFAT pathway.Can J Physiol Pharmacol. 2012; 90(12):1611-22
25. Zhu W, Woo AY, Zhang Y, Cao CM, Xiao RP. β-adrenergic receptor subtype signaling in the heart: from bench to the bedside.Curr Top Membr. 2011; 67:191-204.
26. Chakir K, Zhu W (co-corresponding author, equal first author), Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP RGS2 is a primary terminator of β(2)-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol. 2011;50(6):1000-7.
27. Zhang W, Qi F, Chen DQ, Xiao WY, Wang J, Zhu WZ.. Ca2+/calmodulin-dependent protein kinase IIdelta orchestrates G-protein-coupled receptor and electric field stimulation-induced cardiomyocyte hypertrophy. Clin Exp Pharmacol Physiol. 2010;37(8):795-802.
28. ZhuW, Woo AY, Yang D, Cheng H, Crow MT, Xiao RP. Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis. J Biol Chem. 2007; 282(14):10833-9.
29. Yang D, Zhu WZ(co-corresponded author), Xiao B, Brochet DX, Chen SR, Lakatta EG, Xiao RP, Cheng H.Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res. 2007; 100(3):399-407.
30. Zhu, WZ, Zeng XK, Zheng M, Xiao RP. The Enigma of ß2-Adrenergic Receptor Gi Signaling in the Heart: The Good, the Bad, and the Ugly. Circulation research, 2005, 97;507-509 (Editor Comments).
31. Zhu WZ, Yang D, Zhang SJ, Chakir K, Cheng H, Lavoie C, Mercier JF, Bouvier M, Hébert TE, Lakatta EG, Xiao RP. Dimerization of b1- and b2-Adrenergic Receptor Subtypes Optimizes b-Adrenergic Modulation of Cardiac Contractility. Cir Res, 2005, 97:244-251.
32. Wang W, Zhu WZ, Wang S, Yang D, Crow MT, Xiao RP, Cheng H. Sustained b1-Adrenergic Stimulation Modulates Cardiac Contractility by Ca2+/Calmodulin Kinase Signaling Pathway. Circ Res. 2004; 95(8):798-806.
33. Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP. Linkage of b1-Adrenergic Stimulation to Apoptotic Heart Cell Death through PKA-Independent Activation of Ca2+/Calmodulin Kinase II. J Clin Invest. 2003, 111(5):617-25.
34. Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by beta 2-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci U S A. 2001; 98:1607-1612.
35. Zhu WZ, Han QD. Mechanism of regulation of Ca2+ sensitization in smooth muscle contraction. Sheng Li Ke Xue Jin Zhan 1997; 28:243-5.
36. Zhu WZ, Kwan CY, Han C. Ca2+-dependence of vasoconstriction mediated by alpla1A-adrenoceptors in perfused rat hindlimb: a pharmacological approach. Life Sci 1998;63:PL 89-94.
37. Zhu W, Zhang Y, Han C Characterization of subtype of alpha1-adrenoceptor mediating vasoconstriction in perfused rat hind limb. Eur J Pharmacol 1997; 329:55-61.
BOOK CHAPTER
Weizhong Zhu, Anthony Yiu-Ho Woo, Yan Zhang, Chun-Mei Cao and Rui-Ping Xiao b-adrenergic receptor subtype signaling in the heart:from Bench to The bedside. Current Topics in membranes, Volume 67, 2011, p191-p204 Elsevier Inc. Chapter 9.