硕士生导师

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包小峰

作者:金飞     日期:2021-10-26   点击数:10  

师资介绍

包小峰:男,19799月生,教授,南通大学药学院副院长,微生物与生化药学研究生导师,江苏省高校青蓝工程中青年学术带头人,南通市“226工程”第二层次培养对象,中国微生物学会人兽共患病病原学专业委员会委员,长期从事微生物感染与防治相关领域的研究。近年来主持完成2国家自然科学基金项目,近年来在PNASAACJ Bacteriol等国内外权威杂志发表学术论文30余篇。


1. 教育经历

 (1) 2002.09–2007.06南京大学生物化学与分子生物学博士,导师:华子春、沈萍萍

 (2) 1998.09–2002.06南京大学生物制药工程学士

2. 科研与学术工作经历

 (1) 2013.01-至今南通大学药学院教授

 (2) 2011.08-2012.12美国新泽西医学和牙科大学药理学系研究助理

 (3) 2007.09-2011.08美国新泽西医学和牙科大学博士后,导师:Huizhou Fan



3. 主持科研项目及人才计划项目情况

  1. 南通市基础科学研究项目,JC2019097,抗衣原体药物的筛选与作用机制研究,2019/07-2021/063万元,完成,主持

  2. 南通市第五期“226工程”第二层次培养对象,2018/08-2021/07完成

  3. 国家自然科学基金青年项目,31400165,靶向单基因模型构建与新型小分子化合物CB抗衣原体分子机制研究,2015/01-2017/1223万元,完成,主持

  4. 国家自然科学基金面上项目,31370209GrgA在衣原体生长发育过程中的基因转录调控机制的研究,2014/01-2017/1280万元,已结题,主持

  5. 江苏省高校青蓝工程中青年学术带头人,2014/06-2017/06,已完成



4. 5年发表论文和专利申请

  1.  Miao Sun#, Wenchengyang Bao#, Chengyu Huang, Changliang Zhang, Guangxian Wang, Runxin Wang, Jiangyu Li, ShaunRoux, Qian Li, Dongmei Zou, Kai Ma*,Xiaofeng Bao*. A novel probiotic formula, BIOCG, protects against alzheimer’s-related cognitive deficits via regulation of dendritic spine dynamics. Curr Alzheimer Res 2021

  2.  Min Ni#, Shunxin Xu#, Ziyi Liu, Yin Xue, Wenxia Xie, Shengju Yang*, Lingyan Liu, Xiaofeng Bao*. Inhibitory activity of pyrroloisoxazolidine derivatives against Chlamydia trachomatis. Biomed Res Int 2021 Mar 13;2021:8889247.

  3.  Miao Sun#, Kai Ma#, Jie Wen, Guangxian Wang, Changliang Zhang, Qi Li, Xiaofeng Bao*, Hui Wang*. A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer's Disease.J Alzheimers Dis2020;73(3):849-865.

  4. Xiaofeng Bao#, Ziyi Liu#, Min Ni, Chao Xia, Shunxin Xu, Shengju Yang*, Yu Zhao*. Synthesis and Assessment of 3-Substituted Phenazines as Novel Antichlamydial Agents. Med Chem 2020; 16:413-421.

  5. Xiaofeng Bao, Xiaowei Yu, Chao Xia, Ningjing Yang, Shengju Yang*, Yu Zhao*. Synthesis and antichlamydial activity of novel phenazines. Lett Drug Des Discov 2019; 16(2):174-181.

  6.  Yin Zhou, Huanhuan Jin, Yu Wu, Liang Chen, Xiaofeng Bao*, Chunfeng Lu*.Gallic acid protects against ethanol-induced hepatocyte necroptosis via an NRF2-dependent mechanism. Toxicol In Vitro 2019; 57:226-232.

  7.  Malhar Desai, Wurihan Wurihan, Rong Di, Joseph D. Fondell, Bryce E. Nickels, Xiaofeng Bao*, Huizhou Fan*. A role for GrgA in regulation of σ28-dependent transcription in the obligate intracellular bacterial pathogen Chlamydia trachomatis. J Bacteriol 2018; pii: JB.00298-18.

  8.  Jian Lin Li#, Ningjing Yang#, Lei Huang, Dandan Chen, Yu Zhao, M. Matt Tang, Huizhou Fan*, Xiaofeng Bao*. Pyocyanin inhibits Chlamydia infection by disabling infectivity of the elementary body and disrupting intracellular growth. Antimicrob Agents Chemother 2018; 62(6). pii: e02260-17.

  9.  Hongzhang Ji#, Changyue Wu#, Min Ni, Nannan Feng, Chan Wang, Yu Zhao, Lingyan Liu, Shengju Yang*, Xiaofeng Bao*. In vitro antichlamydial activity of 1,2,3,5-tetrasubstituted pyrrole derivatives. Chemotherapy 2018; 63(2):95-99.

  10. Xiaofeng Bao, Ying Xue, Chao Xia, Yin Lu, NingjingYang, Yu Zhao*. Synthesis and assessment of novel anti-chlamydial benzylidene acylhydrazides derivatives. Lett Drug Des Discov 2018; 15(1):31-36.

  11.  Jian Lin Li#, Dandan Chen#, Lei Huang, Min Ni, Yu Zhao, Huizhou Fan, Xiaofeng Bao*. Antichlamydial dimeric indole derivatives from marine actinomycete Rubrobacter radiotolerans. Planta medica 2017; 83:805-811.

  12. 申请号:CN 202110591839.7;专利名称:一种密码子优化的沙眼衣原体ctl0286基因及其应用;发明类别:C类;发明人:包小峰,陆春风,孙邈,刘书龙,解文霞,姜和;受理

  13. 申请号:CN 2020111776558;专利名称:异泽兰黄素在制备预防或治疗酒精性肝病药物中的应用;发明类别:C类;发明人:陆春风,包小峰,许文萱,李明娜,吴若曼,周莹,姜毅铭;实审

  14. 申请号:CN 2020107948354;专利名称:没食子酸在制备治疗酒精性肝病的药物中的应用;发明类别:C类;发明人:陆春风,包小峰,吴若曼,任远远,彭秀芳,姜毅铭,周莹;实审

  15. 申请号:CN 202010223202.8;专利名称:一种具有含氮侧链的吩嗪衍生物及其制备方法和应用;发明类别:C类;发明人:赵育,包小峰,朱力;实审

  16. 申请号:CN 202010145928.4;专利名称:一种山荷叶素醚类衍生物及其制备方法和应用;发明类别:C类;发明人:赵育,包小峰,朱力;实审

  17. 申请号:CN 202010075949.3;专利名称:一种山荷叶素杂环衍生物及其制备方法和应用;发明类别:C类;发明人:赵育,沈卫东,包小峰,朱力;实审