范博义
师资介绍
范博义，男，汉族，1989年01月生，博士，副教授，硕士生导师。入选江苏高校“青蓝工程”优秀青年骨干教师和江苏省“科技副总”。
教育经历：
2005.09-2009.06华南理工大学，制药工程，学士
2010.09-2015.06中国药科大学，中药学，博士
工作经历：
2015.11-2020.07南通大学，药学院，讲师
2019.11-2020.11美国Scripps研究所，化学系，访问学者
2020.07-至今 南通大学，药学院，副教授
研究方向：
天然药物化学，中药学
社会学术兼职：
中华中医药学会中药化学分会青年委员
基金项目：
江苏省高校“青蓝工程”优秀青年骨干教师培养对象，2024/07-2027/07，在研，主持
国家自然科学基金面上项目，32370419，树脂糖苷类Sec61α抑制剂的发现及其潜在抗冠状病毒活性研究，2024/01-2027/12，在研，主持
江苏省产学研合作项目，BY20230349，基于功效及香气特征的烟用天然中草药提取物的研究与开发，2023/06-2024/06，已结题，主持
南通市科技项目，JC2021094，香樟叶中天然活性化合物的发现及其药理机制研究，2021/07-2023/06，已结题，主持
国家自然科学基金青年项目，31800281，基于自噬-溶酶体通路的土丁桂中潜在抗阿尔茨海默症树脂糖苷类成分的发现及其作用机制研究，2019/01-2021/12，已结题，主持，已结题
南通市科技项目，MS12016038，土丁桂中新颖抗AD活性成分及作用机制研究，2016.10-2018.09，已结题，主持
科研成果：
长期从事中药学及天然药物化学的科研工作，主要聚焦于天然寡糖脂类活性成分的开发和利用，已构建成熟的高效研究策略。迄今已对菟丝子、土丁桂、毛牵牛等多种传统中草药进行研究，发现一系列结构新颖、活性良好的天然寡糖脂类成分，为药物开发提供新颖的先导化合物。主持国家自然基金面上项目及青年项目各1项，江苏省产学研项目1项，南通市科研项目2项。以第一作者或通讯作者在Medicinal Research Reviews, Organic Letters, Journal of Natural Products等国内外专业期刊发表学术论文30余篇，授权发明专利3项。
代表性论文：
1. Wen-Jie Cui#, Ke Nie#, Fan Jin, Peng-Cheng Li, Qiong-Qiong Hou, Tian-Wen Hu, Guang-Hui Tian, Yang He,Bo-Yi Fan*, Guan Wang*, Jing-Shan Shen. N-aryl-N-acyl diamine derivatives as novel selective serotonin/norepinephrine transporter inhibitors for the treatment of premature ejaculation.European Journal of Medicinal Chemistry, 2026, 310, 118771.
2.Bo-Yi Fan#, Cui Su#, Xin Lan, Su-Peng Guo, Tian-Zi Qi, Jin-Ping Gu, Xin-Yu Wang, Bin Lin, Min Yang, Guang-Tong Chen, Jia-Lie Luo*, Jian-Zhong Yu*, Wen-Li Wang*. Discovery of ent-kaurane diterpenoid glucosides fromCuscuta japonica seeds and their α-glucosidase inhibitory activity.Journal of Molecular Structure, 2026, 1358, 145255.
3. Yu-Xin Li#, Xu-Jia He#, Yan Chen, Jin-Ping Gu, Tian-Zi Qi, Hong Gu, Xin-Yi Zhu, Min Yang, Yu-Chneg Gu, Bai Ling, Guang-Tong Chen, Wen-Li Wang*, Jia-Lie Luo*,Bo-Yi Fan*. Controlins I-X, Resin glycosides from the seeds ofConvolvulus tricolor and their biological activities.Journal of Natural Products 2025, 88, 415-426.
4. Jin-Ping Gu#, Tian-Zi Qi#, Dong-Rong Zhu#, Xu-Jia He, Su-Peng Guo, Xin Lan, Hong Gu, Jia-Lie Luo, Min Yang, Yu-Cheng Gu, Wen-Li Wang*, Guang-Tong Chen*,Bo-Yi Fan*. Isolation of pentasaccharide resin glycosides from the whole plants ofIpomoea biflora and their cytotoxic activities.Phytochemistry, 2025, 236, 114494.
5. Su-Peng Guo#, Ye He#, Xin Lan, Tian-Zi Qi, Jin-Ping Gu, Jia Guo, Xin-Yu Wang, Min Yang, Wen-Li Wang, Guang-Tong Chen*,Bo-Yi Fan*. Resin glycosides with α-glucosidase and protein tyrosine phosphatase 1B inhibitory activities from the seeds ofCuscuta japonica.Biomolecules, 2025, 15, 1465.
6. Wen-Li Wang, Qi Gao, Jian-QI Wei, Jian Xiao, Kai Chen, Bin Lin, Min Yang, An-Dong Wang, Guang-Tong Chen*,Bo-Yi Fan*. New oligomeric terpenoids fused with an oxazoline ring linkage from cones oftaxodium ascendens and their biological activities.Journal of Molecular Structure 2025, 1321, 140206.
7.Bo-Yi Fan#*, Xing Jiang#, Yu-Xin Li, Wen-Li Wang, Min Yang, Jian-Lin Li, An-Dong Wang, Guang-Tong Chen*. Chemistry and biological activity of resin glycosides from Convolvulaceae species.Medicinal Research Reviews 2022, 42(6), 2025-2066.
8. Wen-Li Wang#, Yu-Xin Li#, Ye He#, Xing Jiang, Ying Yi, Xi-Han Zhang, Shi-Yu Zhang, Guang-Tong Chen, Min Yang, Jia-Lie Luo,Bo-Yi Fan*. Progress in the total synthesis of resin glycosides.Frontiers in Chemistry 2022, 10, 1036954.
9. You-Jia Lu#, Yi-Fei Tang#, Yan-Ni Wu, Xue-Ying Zhang, Ying Yi, Wen-Li Wang*, An-Dong Wang, Min Yang,Bo-Yi Fan*, Guang-Tong Chen*. Microbial transformation of betulonic acid byCircinella muscae CGMCC 3.2695 and anti-neuroinflammatory activity of the products.Phytochemistry 2022, 204, 113431.
10. Kai-Nan Song#, You-Jia Lu#, Cheng-Jiao Chu, Yan-Ni Wu, Hui-Lian Huang,Bo-Yi Fan*, and Guang-Tong Chen*. Biotransformation of betulonic acid by the fungusRhizopus arrhizus CGMCC 3.868 and antineuroinflammatory activity of the biotransformation products.Journal of Natural Products 2021, 84(10), 2664–2674.
11.Bo-Yi Fan, Yun Lu, Min Yang, Jian-Lin Li*, Guang-Tong Chen*. Evolvulins I and II, resin glycosides with a trihydroxy aglycone unit fromEvolvulus alsinoides.Organic Letters 2019, 21, 6548–6551.
12.Bo-Yi Fan, Ye He, Yun Lu, Min Yang, Qing Zhu, Guang-Tong Chen*, Jian-Lin Li*.Glycosidic acids with unusual aglycone units fromConvolvulus arvensis. Journal of Natural Products2019, 82, 1593-1598.
13. Guang-Tong Chen, Yun Lu, Min Yang, Jian-Lin Li*,Bo-Yi Fan*. Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: a systematic review.Phytotherapy Research 2018, 32(5), 823-864.
14.Bo-Yi Fan, Zhong-Rui Li, Ting Ma, Yu-Cheng Gu, Hui-Jun Zhao,Jian-Guang Luo*, Ling-Yi Kong*. Further screening of the resin glycosides in the edible water spinach and characterisation on their mechanism of anticancer potential.Journal of Functional Foods2015, 19, 141-154.
15.Bo-Yi Fan, Yu-Cheng Gu, Ye He, Zhong-Rui Li, Jian-Guang Luo,* Ling-Yi Kong*. Cytotoxic resin glycosides fromIpomoea aquatica and their effects on intracellular Ca2+ concentrations.Journal of Natural Products2014, 77, 2264−2272.
16.Bo-Yi Fan, Jian-Guang Luo, Yu-Cheng Gu, Ling-Yi Kong*. Unusual ether-type resin glycoside dimers from the seeds ofCuscuta chinensis.Tetrahedron 2014, 70, 2003-2014.
授权专利:
1.田旋花总树脂糖苷提取物及其制备方法和医学用途。发明人：范博义，赵文迪，陆云，杨敏。专利号：ZL201810244054.0。
2.开环树脂糖苷类衍生物及其制备方法与应用。发明人：范博义，郭佳，兰欣，郭苏鹏，王雯丽，顾泓。专利号：ZL202510063883.9。
3.糖脂类衍生物、制备方法及其在制备抗神经损伤药物中的应用。发明人：范博义， 郭苏鹏，兰欣，王雯丽，范蕊，陈广通。专利号：ZL202510063886.2。