陈婷婷

师资介绍

南通大学药学院药理系副教授，硕士生导师，神经退行性疾病如老年痴呆等的药物治疗和预防

教育经历

(1) 2015-09至2018-07,南京医科大学,药理学,博士

(2) 2013-09至2015-06,南京医科大学,生理学,硕士

(3) 2008-09至2013-06,南京医科大学,临床药学,学士

工作经历

(1) 2021-07至 今,南通大学,药学院,副教授

(2) 2018-09至2021-06,南通大学,药学院,讲师

(3) 2019-12至2020-12,南洋理工大学,访问学者

研究方向

神经退行性疾病的药物治疗和预防

社会学术兼职

江苏省药理学会临床前药理专委会委员

在研/主持基金项目

(1)南通市自然科学基金，面上基金，JC2024060，法尼基硫代水杨酸FTS通过抑制半乳凝素Gal-3多途径改善阿尔 兹海默症神经炎性反应的机制研究，2024–10至2027–9，6万，在研，主持。

(2)国家自然科学基金，青年基金，81901098，抑制Ras法尼基化改善阿尔兹海默病认知功能的分子机制研究，2020–01至2022–12，20.50万，结题，主持。

(3)江苏省自然科学基金，青年基金，BK20190923，抑制Ras法尼基化抗痴呆的神经保护作用机制研究，2019–07至2022–06，20万，结题，主持。

(4)南通市基础科学研究项目，JC2018009，小G蛋白Ras活性抑制对阿尔兹海默病认知功能的调控机制，2018–07至2020–06，5万，结题，主持。

科研成果

见论文

代表性论文

(1) Mengting Yang, ShunChao Dai, Shixin Li, Zihang Xu,Tingting Chen. Involvement and mechanisms of Aβ and Tau in neuroinflammatory response of Alzheimer‘s disease[J].Current Neuropharmacology, 2026 May 15.

(2)Qing Qiu#, Mengting Yang#, Danfeng Gong#, Haiying Liang*,Tingting Chen*. Potassium and calcium channels in different nerve cells act as therapeutic targets of neurological disorders.Neural Regeneration Research. 2025 May 1;20(5)

(3)Shengchun Lou#, Danfeng Gong#, Mengting Yang, Qing Qiu, Jialie Luo*,Tingting Chen*. Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF. International Journal of Molecular Sciences, Int. J. Mol. Sci. 2024, 25, 5123.

(4) Qing Qiu#, Cui Li#, Xiaoli Zhao, Mengting Yang, Haiying Liang, Shushu Ding, Tingting Chen*,Farnesylthiosalicylic acid through inhibition of galectin-3 improves neuroinflammation in Alzheimer’s disease via multiple pathways.CNS Neuroscience & Therapeutics.2024 Nov;30(11)

(5) Chengyun Cai; Lifeng Wang; Shixin Li; Shengchun Lou; Jia-Lie Luo; Ding-Yi Fu; Tingting Chen ; Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation,The Journal of Neuroscience, 2022, 42(31): 6090-6107. 

(6)Chao Yang; Huan-Yu Ni; Jia-Jie Yin; Ting Zhou; Qiu-Xiang Gu; TingTing Chen; Cheng-Yun Cai; Atorvastatin ameliorates depressive behaviors via regulation of α7nAChR expression by PI3K/Akt-BDNF pathway in mice.BBRC. 2022 Feb 19;593:57-64.

(7)Wee Meng Lim; Eunice W M Chin; Bor Luen Tang; Tingting Chen; Eyleen L K Goh; WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons.Front Mol Neurosci.2021 Nov 10;14:762142. doi: 10.3389/fnmol.2021.762142.

(8)Tingting Chen; Chengyun Cai; Lifeng Wang; Shixin Li; Ling Chen ; Farnesyl transferase inhibitor lonafarnib enhances α7nAChR expression through inhibiting DNA methylation of CHRNA7 and increases α7nAChR membrane trafficking,Frontiers in Pharmacology, 2020, 11.

(9)Tingting Chen; Ya Wang; Tingting Zhang; Baofeng Zhang; Lei Chen; Liandong Zhao; Ling Chen; Simvastatin enhances activity and trafficking of alpha 7 nicotinic acetylcholine receptor in hippocampal neurons through PKC and CaMKII signaling pathways,Frontiers in Pharmacology, 2018, 9: 0-362. 

(10)Chen T, Zhang B, Li G, Chen L, Chen L. Simvastatin enhances NMDA

receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons.Neuropharmacology, 2016 Aug;107:411-21. 

(11)Tingting Chen; Motoki Tanaka; Ya Wang; Sha Sha; Kishio Furuya; Ling Chen; Masahiro Sokabe; Neurosteroid dehydroepiandrosterone enhances activity and trafficking of astrocytic GLT-1 via sigma(1) receptor-mediated PKC activation in the hippocampal dentate gyrus of rats,GLIA, 2017, 65(9): 1491-1503. 

(12) Zhou L*, Chen T*, Li G, Wu C, Wang C, Li L, Sha S, Chen L, Liu G, Chen L. Activation of PPARγ ameliorates spatial cognitive deficits through restoring expression of AMPA receptors in seipin knockout mice.J Neurosci., 2016 Jan 27;36(4):1242-53. 

(13)Tingting Chen; Conghui Wang; Sha Sha; Libin Zhou; Lei Chen; Ling Chen ; Simvastatin enhances spatial memory and long-term potentiation in hippocampal CA1 via upregulation of alpha 7 nicotinic acetylcholine receptor,Molecular Neurobiology,2016, 53(6): 4060-4072.