陈云

陈云，女，汉族，1987年10月生，副教授，博士研究生

教育经历：

2006.09-2011.06山东第一医科大学，药学（临床药学方向），学士

2011.09-2014.06南通大学，药理学，硕士

2017.09-2020.06南通大学，基础医学，博士

工作经历：

2014.07-2017.08南通卫生健康职业学院，药学系，助教

2020.07-2024.09南通大学，药学院药理学系，讲师

2024.10-今 南通大学，药学院药理学系，副教授

研究方向：

心血管药理学，心血管病理生理学

学术兼职：

江苏省药理学会临床前药理专业委员会委员

基金项目：

1.  江苏省高等学校自然科学研究面上项目，21KJB310014，TRADD调控心肌缺血再灌注损伤中坏死性凋亡的作用及机制研究，2021/10-2023/09，3万元，主持

2.      国家自然科学基金青年项目，82200313，XBP1介导TRADD转录进而调控焦亡在糖尿病心肌病中的作用及机制研究，2023/01-2025/12，30万元，主持

代表性论文：

1. Danning Shen, Zhaojing Chen, Danyi Cao, Guoliang Meng *, Jiahai Shi*, Yun Chen(陈云，共同通讯作者).Cell death regulation: A novel way of natural products to treat myocardial hypertrophy. Ageing Research Reviews. 120 (2026), 103222.

2. Danyi Cao, Han Han, Deyong Yue, Guojun Shi, Yun Chen* (陈云，共同通讯作者), Jiahai Shi, Guoliang Meng; Distinct types of regulated cell death in atherosclerosis. Journal of Pharmaceutical Analysis. 2026, 16: 101431.

3. Yangyang Zheng, Danning Shen, Xiaolu Peng, Wenqng San, Qianyou Zhou, Shengju Yang, Guoliang Meng, Jiahai Shi, Yun Chen* (陈云，共同通讯作者); TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy, Acta Pharmacologica Sinica, 2025; 46(4): 940-950.

4. Qianyou Zhou, Xintong Ge, Zhaojing Chen, Danyi Cao, Yun Chen* (陈云，共同通讯作者), Jiahai Shi, Guoliang Meng; Distinct types of protein modifications in diabetic endothelial dysfunction, Cardiovasc Diabetol, 2025; 24(1): 287.

5. Wenqing San, Qianyou Zhou, Danning Shen, Danyi Cao, Yun Chen* (陈云，共同通讯作者), Guoliang Meng*; Roles of retinoic acid-related orphan receptor α in high glucose-induced cardiac fibroblasts proliferation, Front Pharmacol. 2025; 16:1539690.

6. Zheng Y#, Xu Y#, Ji L, San W, Shen D, Zhou Q, Meng G*, Shi J*, Chen Y* (陈云，共同通讯作者). Roles of distinct nuclear receptors in diabetic cardiomyopathy. Front Pharmacol. 2024; 15: 1423124.

7. Jieru Shen, Wenqing San, Yangyang Zheng, Shuping Zhang, Danyi Cao,Yun Chen* (陈云，共同通讯作者), Guoliang Meng*; Different types of cell death in diabetic endothelial dysfunction. Biomedicine & Pharmacotherapy, 2023, 168:115802.

8. Zhang S#, Shen J#, Zhu Y, Zheng Y, San W, Cao D, Chen Y* (陈云，共同通讯作者), Meng G*. Hydrogen sulfide promoted retinoic acid-related orphan receptor α transcription to alleviate diabetic cardiomyopathy. Biochem Pharmacol. 2023; 215: 115748.

9. Chen Y#(陈云，第一作者), Zheng Y#, Chen R, Shen J, Zhang S, Gu Y, Shi J*, Meng G* . Dihydromyricetin attenuates diabetic cardiomyopathy by inhibiting oxidative stress, inflammation and necroptosis via sirtuin 3 activation. Antioxidants. 2023; 12(1): 200.

10. Chen Y（陈云，第一作者）, Gu Y, Xiong X, Zheng Y, Liu X, Wang W, Meng G*. Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases. Biomed Pharmacother. 2022; 153: 113467.

11. Yun Chen#(陈云，第一作者), Yuyun Hua#, Yuyun Hua, Yue Ding , Guoliang Meng, Wei Zhang. RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation. Oxid Med Cell Longev. 2021; 2021: 6617816.

12. Chen Y#(陈云，第一作者), Hua Y#, Li X, Arslan IM, Zhang W, Meng G*. Distinct types of cell death and the implication in diabetic cardiomyopathy. Front Pharmacol. 2020; 11: 42.

13. Yuyun Hua#, Yue Zhang#, Weiwei Gong, Yue Ding, Jieru Shen, Hua Li, Yun Chen*(陈云，共同通讯作者), Guoliang Meng*. Dihydromyricetin improves endothelial dysfunction in diabetic mice via oxidative stress inhibition in a SIRT3-dependent manner. Int J Mol Sci. 2020; 21(18): 6699.

14. Yun Chen#(陈云，第一作者), Huiqin Luo#, Linlin Sun#, Mengting Xu, Jin Yu, Lulu Liu, Jinyao Zhang, Yuqin Wang, Hongxia Wang, Xiaofeng Bao, Guoliang Meng*. Dihydromyricetin attenuates myocardial hypertrophy induced by transverse aortic constriction via oxidative stress inhibition and SIRT3 pathway enhancement. Int J Mol Sci. 2018; 19(9): 2592.